True 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugs.

True 3q chromosomal amplification in squamous cell lung carcinoma by FISH and aCGH molecular analysis: impact on targeted drugs.

Squamous lung carcinoma lacks specific "ad hoc" therapies. Amplification of chromosome 3q is the most common genomic aberration and this region harbours genes having role as novel targets for therapeutics. There is no standard definition on how to score and report 3q amplification. False v...

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Autores principales: Matteo Brunelli, Emilio Bria, Alessia Nottegar, Sara Cingarlini, Francesca Simionato, Anna Caliò, Albino Eccher, Claudia Parolini, Antonio Iannucci, Eliana Gilioli, Serena Pedron, Francesco Massari, Giampaolo Tortora, Ioana Borze, Sakari Knuutila, Stefano Gobbo, Antonio Santo, Luca Tondulli, Francesco Calabrò, Guido Martignoni, Marco Chilosi
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/c836151bf57a4429b7a03c2bb3ae5354
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