Molecular-Genetic Aspects of Breast Cancer

Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control...

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Autores principales:	Krasteva M., Angelova Sv, Gospodinova Zl
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2014
Materias:	breast cancer tumor suppressor genes proto-oncogenes mutations dna hypermethylation clinical impact Medicine R
Acceso en línea:	https://doaj.org/article/c837e177569b4e3695358d45cfb5ccb9
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spelling	oai:doaj.org-article:c837e177569b4e3695358d45cfb5ccb92021-12-02T16:42:08ZMolecular-Genetic Aspects of Breast Cancer0324-175010.1515/amb-2014-0024https://doaj.org/article/c837e177569b4e3695358d45cfb5ccb92014-12-01T00:00:00Zhttps://doi.org/10.1515/amb-2014-0024https://doaj.org/toc/0324-1750Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control and maintenance of genome integrity. Their function may be disrupted as a result of alterations in gene sequence or misregulation of gene expression including alterations in DNA methylation pattern. The present review summarizes the main findings on major breast cancer related genes BRCA1/2, p53, ATM, CHEK2, HER2, PIK3CA and their tumorigenic inactivation/activation. The potential clinical importance of these genes with respect to patients’ prognosis and therapy are also discussed. The possible implication of other putative breast cancer related genes is also outlined. The first elaborate data on the genetic and epigenetic status of the above mentioned genes concerning Bulgarian patients with the sporadic form of the disease are presented. The studies indicate for a characteristic mutational spectrum in some of the genes for the Bulgarian patients and specific correlation between the status of different genes and clinicopathological characteristics.Krasteva M.Angelova SvGospodinova ZlSciendoarticlebreast cancertumor suppressor genesproto-oncogenesmutationsdna hypermethylationclinical impactMedicineRENActa Medica Bulgarica, Vol 41, Iss 2, Pp 67-79 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer tumor suppressor genes proto-oncogenes mutations dna hypermethylation clinical impact Medicine R
spellingShingle	breast cancer tumor suppressor genes proto-oncogenes mutations dna hypermethylation clinical impact Medicine R Krasteva M. Angelova Sv Gospodinova Zl Molecular-Genetic Aspects of Breast Cancer
description	Breast cancer is the most frequent malignancy among women. Advances in breast cancer knowledge have deciphered the involvement of a number of tumor suppressor genes and proto-oncogenes in disease pathogenesis. These genes are part of the complex biochemical pathways, which enable cell cycle control and maintenance of genome integrity. Their function may be disrupted as a result of alterations in gene sequence or misregulation of gene expression including alterations in DNA methylation pattern. The present review summarizes the main findings on major breast cancer related genes BRCA1/2, p53, ATM, CHEK2, HER2, PIK3CA and their tumorigenic inactivation/activation. The potential clinical importance of these genes with respect to patients’ prognosis and therapy are also discussed. The possible implication of other putative breast cancer related genes is also outlined. The first elaborate data on the genetic and epigenetic status of the above mentioned genes concerning Bulgarian patients with the sporadic form of the disease are presented. The studies indicate for a characteristic mutational spectrum in some of the genes for the Bulgarian patients and specific correlation between the status of different genes and clinicopathological characteristics.
format	article
author	Krasteva M. Angelova Sv Gospodinova Zl
author_facet	Krasteva M. Angelova Sv Gospodinova Zl
author_sort	Krasteva M.
title	Molecular-Genetic Aspects of Breast Cancer
title_short	Molecular-Genetic Aspects of Breast Cancer
title_full	Molecular-Genetic Aspects of Breast Cancer
title_fullStr	Molecular-Genetic Aspects of Breast Cancer
title_full_unstemmed	Molecular-Genetic Aspects of Breast Cancer
title_sort	molecular-genetic aspects of breast cancer
publisher	Sciendo
publishDate	2014
url	https://doaj.org/article/c837e177569b4e3695358d45cfb5ccb9
work_keys_str_mv	AT krastevam moleculargeneticaspectsofbreastcancer AT angelovasv moleculargeneticaspectsofbreastcancer AT gospodinovazl moleculargeneticaspectsofbreastcancer
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Molecular-Genetic Aspects of Breast Cancer

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