Update on sepsis-associated acute kidney injury: emerging targeted therapies

James F Doyle,1 Lui G Forni1,2 1Department of Intensive Care, Medicine and Surrey Peri-Operative Anaesthesia and Critical Care Collaborative Research Group, Royal Surrey County Hospital NHS Foundation Trust, 2Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK Abstrac...

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Autores principales:	Doyle JF, Forni LG
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Sepsis Acute kidney injury Novel Targeted Therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c83cb04062f249bbbda340c21e741154
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spelling	oai:doaj.org-article:c83cb04062f249bbbda340c21e7411542021-12-02T03:57:47ZUpdate on sepsis-associated acute kidney injury: emerging targeted therapies1177-5491https://doaj.org/article/c83cb04062f249bbbda340c21e7411542016-11-01T00:00:00Zhttps://www.dovepress.com/update-on-sepsis-associated-acute-kidney-injury-emerging-targeted-ther-peer-reviewed-article-BTThttps://doaj.org/toc/1177-5491James F Doyle,1 Lui G Forni1,2 1Department of Intensive Care, Medicine and Surrey Peri-Operative Anaesthesia and Critical Care Collaborative Research Group, Royal Surrey County Hospital NHS Foundation Trust, 2Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK Abstract: Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies. Keywords: sepsis, acute kidney injury, novel targeted therapy outcomeDoyle JFForni LGDove Medical PressarticleSepsis Acute kidney injury Novel Targeted TherapyMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol Volume 10, Pp 149-156 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sepsis Acute kidney injury Novel Targeted Therapy Medicine (General) R5-920
spellingShingle	Sepsis Acute kidney injury Novel Targeted Therapy Medicine (General) R5-920 Doyle JF Forni LG Update on sepsis-associated acute kidney injury: emerging targeted therapies
description	James F Doyle,1 Lui G Forni1,2 1Department of Intensive Care, Medicine and Surrey Peri-Operative Anaesthesia and Critical Care Collaborative Research Group, Royal Surrey County Hospital NHS Foundation Trust, 2Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK Abstract: Sepsis-associated acute kidney injury (SA-AKI) is an independent predictor of increased mortality and morbidity. It is essential that further advances in the treatment of sepsis should prioritize targeted therapies in SA-AKI in order to improve these bleak outcomes. As yet, a unique therapy that effectively reduces the impact of acute kidney injury has not been demonstrated. However, the emergence of novel targeted therapies, perhaps in combination, has the possibility of significantly reducing the long-term sequelae of an episode of SA-AKI. In this review, we will focus on the shared etiology of these conditions and how this is managed with targeted therapy and finally the emerging novel therapies that may play an additional role to current treatment strategies. Keywords: sepsis, acute kidney injury, novel targeted therapy outcome
format	article
author	Doyle JF Forni LG
author_facet	Doyle JF Forni LG
author_sort	Doyle JF
title	Update on sepsis-associated acute kidney injury: emerging targeted therapies
title_short	Update on sepsis-associated acute kidney injury: emerging targeted therapies
title_full	Update on sepsis-associated acute kidney injury: emerging targeted therapies
title_fullStr	Update on sepsis-associated acute kidney injury: emerging targeted therapies
title_full_unstemmed	Update on sepsis-associated acute kidney injury: emerging targeted therapies
title_sort	update on sepsis-associated acute kidney injury: emerging targeted therapies
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c83cb04062f249bbbda340c21e741154
work_keys_str_mv	AT doylejf updateonsepsisassociatedacutekidneyinjuryemergingtargetedtherapies AT fornilg updateonsepsisassociatedacutekidneyinjuryemergingtargetedtherapies
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Update on sepsis-associated acute kidney injury: emerging targeted therapies

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