A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice

Abstract Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a deriva...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aneta Cheda, Ewa M. Nowosielska, Jerzy Gebicki, Andrzej Marcinek, Stefan Chlopicki, Marek K. Janiak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c83dc100732c40d3997195b5dd358f9f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c83dc100732c40d3997195b5dd358f9f
record_format	dspace
spelling	oai:doaj.org-article:c83dc100732c40d3997195b5dd358f9f2021-12-02T14:26:13ZA derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice10.1038/s41598-021-86870-32045-2322https://doaj.org/article/c83dc100732c40d3997195b5dd358f9f2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86870-3https://doaj.org/toc/2045-2322Abstract Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a derivative of vitamin B3, significantly (1.6 to 1.9 times) prolonged survival of BALB/c mice irradiated at LD30/30 (6.5 Gy), LD50/30 (7.0 Gy) or LD80/30 (7.5 Gy) of γ-rays when the MNA administration started as late as 7 days post irradiation. A slightly less efficient and only after the highest dose (7.5 Gy) of γ-rays was another vitamin B3 derivative, 1-methyl-3-acetylpyridine (1,3-MAP) (1.4-fold prolonged survival). These pro-survival effects did not seem to be mediated by stimulation of haematopoiesis, but might be related to anti-inflammatory and/or anti-thrombotic properties of the vitamin B3 derivatives. Our results show that MNA may represent a prototype of a radioremedial agent capable of mitigating the severity and/or progression of radiation-induced injuries when applied several hours or days after exposure to high doses of ionizing radiation.Aneta ChedaEwa M. NowosielskaJerzy GebickiAndrzej MarcinekStefan ChlopickiMarek K. JaniakNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aneta Cheda Ewa M. Nowosielska Jerzy Gebicki Andrzej Marcinek Stefan Chlopicki Marek K. Janiak A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
description	Abstract Most, if not all, of the hitherto tested substances exert more or less pronounced pro-survival effects when applied before or immediately after the exposure to high doses of ionizing radiation. In the present study we demonstrate for the first time that 1-methyl nicotinamide (MNA), a derivative of vitamin B3, significantly (1.6 to 1.9 times) prolonged survival of BALB/c mice irradiated at LD30/30 (6.5 Gy), LD50/30 (7.0 Gy) or LD80/30 (7.5 Gy) of γ-rays when the MNA administration started as late as 7 days post irradiation. A slightly less efficient and only after the highest dose (7.5 Gy) of γ-rays was another vitamin B3 derivative, 1-methyl-3-acetylpyridine (1,3-MAP) (1.4-fold prolonged survival). These pro-survival effects did not seem to be mediated by stimulation of haematopoiesis, but might be related to anti-inflammatory and/or anti-thrombotic properties of the vitamin B3 derivatives. Our results show that MNA may represent a prototype of a radioremedial agent capable of mitigating the severity and/or progression of radiation-induced injuries when applied several hours or days after exposure to high doses of ionizing radiation.
format	article
author	Aneta Cheda Ewa M. Nowosielska Jerzy Gebicki Andrzej Marcinek Stefan Chlopicki Marek K. Janiak
author_facet	Aneta Cheda Ewa M. Nowosielska Jerzy Gebicki Andrzej Marcinek Stefan Chlopicki Marek K. Janiak
author_sort	Aneta Cheda
title	A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
title_short	A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
title_full	A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
title_fullStr	A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
title_full_unstemmed	A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice
title_sort	derivative of vitamin b3 applied several days after exposure reduces lethality of severely irradiated mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c83dc100732c40d3997195b5dd358f9f
work_keys_str_mv	AT anetacheda aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT ewamnowosielska aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT jerzygebicki aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT andrzejmarcinek aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT stefanchlopicki aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT marekkjaniak aderivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT anetacheda derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT ewamnowosielska derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT jerzygebicki derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT andrzejmarcinek derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT stefanchlopicki derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice AT marekkjaniak derivativeofvitaminb3appliedseveraldaysafterexposurereduceslethalityofseverelyirradiatedmice
_version_	1718391395101704192

A derivative of vitamin B3 applied several days after exposure reduces lethality of severely irradiated mice

Ejemplares similares