Mechano-modulatory synthetic niches for liver organoid derivation

3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not requi...

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Autores principales:	Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz, Sandro Nuciforo, Markus H. Heim, Matthias P. Lutolf, Kristina Schoonjans
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8411ec2ce88475e9d68ea7685bcb371
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spelling	oai:doaj.org-article:c8411ec2ce88475e9d68ea7685bcb3712021-12-02T15:23:10ZMechano-modulatory synthetic niches for liver organoid derivation10.1038/s41467-020-17161-02041-1723https://doaj.org/article/c8411ec2ce88475e9d68ea7685bcb3712020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17161-0https://doaj.org/toc/2041-17233D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.Giovanni SorrentinoSaba RezakhaniEce YildizSandro NuciforoMarkus H. HeimMatthias P. LutolfKristina SchoonjansNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Giovanni Sorrentino Saba Rezakhani Ece Yildiz Sandro Nuciforo Markus H. Heim Matthias P. Lutolf Kristina Schoonjans Mechano-modulatory synthetic niches for liver organoid derivation
description	3D liver organoids hold great promise for regenerative medicine but the use of ill-defined matrices limits their potential. Here, the authors generate human and mouse liver organoids using a chemically defined matrix, and reveal a link between matrix stiffness and organoid growth that does not require acto-myosin contraction.
format	article
author	Giovanni Sorrentino Saba Rezakhani Ece Yildiz Sandro Nuciforo Markus H. Heim Matthias P. Lutolf Kristina Schoonjans
author_facet	Giovanni Sorrentino Saba Rezakhani Ece Yildiz Sandro Nuciforo Markus H. Heim Matthias P. Lutolf Kristina Schoonjans
author_sort	Giovanni Sorrentino
title	Mechano-modulatory synthetic niches for liver organoid derivation
title_short	Mechano-modulatory synthetic niches for liver organoid derivation
title_full	Mechano-modulatory synthetic niches for liver organoid derivation
title_fullStr	Mechano-modulatory synthetic niches for liver organoid derivation
title_full_unstemmed	Mechano-modulatory synthetic niches for liver organoid derivation
title_sort	mechano-modulatory synthetic niches for liver organoid derivation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c8411ec2ce88475e9d68ea7685bcb371
work_keys_str_mv	AT giovannisorrentino mechanomodulatorysyntheticnichesforliverorganoidderivation AT sabarezakhani mechanomodulatorysyntheticnichesforliverorganoidderivation AT eceyildiz mechanomodulatorysyntheticnichesforliverorganoidderivation AT sandronuciforo mechanomodulatorysyntheticnichesforliverorganoidderivation AT markushheim mechanomodulatorysyntheticnichesforliverorganoidderivation AT matthiasplutolf mechanomodulatorysyntheticnichesforliverorganoidderivation AT kristinaschoonjans mechanomodulatorysyntheticnichesforliverorganoidderivation
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Mechano-modulatory synthetic niches for liver organoid derivation

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