Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B

Abstract Recently, hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of hepatitis B virus (HBV) infection. This study aimed to investigate whether serum quantitative HBcrAg (qHBcrAg) was a satisfactory surrogate marker of intrahepatic covalently closed circular DNA...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	En-Qiang Chen, Shu Feng, Meng-Lan Wang, Ling-Bo Liang, Ling-Yun Zhou, Ling-Yao Du, Li-Bo Yan, Chuan-Min Tao, Hong Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8415f2e7e02441e8a68b378225170e8
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8415f2e7e02441e8a68b378225170e8
record_format	dspace
spelling	oai:doaj.org-article:c8415f2e7e02441e8a68b378225170e82021-12-02T15:05:17ZSerum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B10.1038/s41598-017-00111-02045-2322https://doaj.org/article/c8415f2e7e02441e8a68b378225170e82017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00111-0https://doaj.org/toc/2045-2322Abstract Recently, hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of hepatitis B virus (HBV) infection. This study aimed to investigate whether serum quantitative HBcrAg (qHBcrAg) was a satisfactory surrogate marker of intrahepatic covalently closed circular DNA (cccDNA). A total of 139 patients with liver biopsy were enrolled, consisting of 59 patients in immune tolerance (IT) phase, 52 patients in immune clearance (IC) phase, 18 patients in low-replication (LR) phase, and 10 patients in reactivation phase. All patients in IC phase have received entecavir (ETV) therapy, and 32 of them undergone a second liver biopsy at 24 months. Among those patients, qHBcrAg was strongly correlated with intrahepatic cccDNA, which is superior to that of qHBsAg and HBV DNA. And similar findings were also observed in patients in IT, IC, LR and reactivation phases. Among the 32 ETV-treated patients with a second liver biopsy in IC phase, the decline of intrahepatic cccDNA was accompanied by changes in both qHBcrAg and qHBsAg. However, as compared to qHBsAg, the change of qHBcrAg was more strongly associated with intrahepatic cccDNA-decline. In summary, serum qHBcrAg should be a satisfactory surrogate of intrahepatic HBV cccDNA in CHB patients.En-Qiang ChenShu FengMeng-Lan WangLing-Bo LiangLing-Yun ZhouLing-Yao DuLi-Bo YanChuan-Min TaoHong TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q En-Qiang Chen Shu Feng Meng-Lan Wang Ling-Bo Liang Ling-Yun Zhou Ling-Yao Du Li-Bo Yan Chuan-Min Tao Hong Tang Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
description	Abstract Recently, hepatitis B core-related antigen (HBcrAg) has been suggested as an additional marker of hepatitis B virus (HBV) infection. This study aimed to investigate whether serum quantitative HBcrAg (qHBcrAg) was a satisfactory surrogate marker of intrahepatic covalently closed circular DNA (cccDNA). A total of 139 patients with liver biopsy were enrolled, consisting of 59 patients in immune tolerance (IT) phase, 52 patients in immune clearance (IC) phase, 18 patients in low-replication (LR) phase, and 10 patients in reactivation phase. All patients in IC phase have received entecavir (ETV) therapy, and 32 of them undergone a second liver biopsy at 24 months. Among those patients, qHBcrAg was strongly correlated with intrahepatic cccDNA, which is superior to that of qHBsAg and HBV DNA. And similar findings were also observed in patients in IT, IC, LR and reactivation phases. Among the 32 ETV-treated patients with a second liver biopsy in IC phase, the decline of intrahepatic cccDNA was accompanied by changes in both qHBcrAg and qHBsAg. However, as compared to qHBsAg, the change of qHBcrAg was more strongly associated with intrahepatic cccDNA-decline. In summary, serum qHBcrAg should be a satisfactory surrogate of intrahepatic HBV cccDNA in CHB patients.
format	article
author	En-Qiang Chen Shu Feng Meng-Lan Wang Ling-Bo Liang Ling-Yun Zhou Ling-Yao Du Li-Bo Yan Chuan-Min Tao Hong Tang
author_facet	En-Qiang Chen Shu Feng Meng-Lan Wang Ling-Bo Liang Ling-Yun Zhou Ling-Yao Du Li-Bo Yan Chuan-Min Tao Hong Tang
author_sort	En-Qiang Chen
title	Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
title_short	Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
title_full	Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
title_fullStr	Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
title_full_unstemmed	Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B
title_sort	serum hepatitis b core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular dna in chronic hepatitis b
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c8415f2e7e02441e8a68b378225170e8
work_keys_str_mv	AT enqiangchen serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT shufeng serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT menglanwang serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT lingboliang serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT lingyunzhou serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT lingyaodu serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT liboyan serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT chuanmintao serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb AT hongtang serumhepatitisbcorerelatedantigenisasatisfactorysurrogatemarkerofintrahepaticcovalentlyclosedcirculardnainchronichepatitisb
_version_	1718388920822005760

Serum hepatitis B core-related antigen is a satisfactory surrogate marker of intrahepatic covalently closed circular DNA in chronic hepatitis B

Ejemplares similares