Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tissue that supports mature T cell development in vit...

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Autores principales:	Sara Campinoti, Asllan Gjinovci, Roberta Ragazzini, Luca Zanieri, Linda Ariza-McNaughton, Marco Catucci, Stefan Boeing, Jong-Eun Park, John C. Hutchinson, Miguel Muñoz-Ruiz, Pierluigi G. Manti, Gianluca Vozza, Carlo E. Villa, Demetra-Ellie Phylactopoulos, Constance Maurer, Giuseppe Testa, Hans J. Stauss, Sarah A. Teichmann, Neil J. Sebire, Adrian C. Hayday, Dominique Bonnet, Paola Bonfanti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c841855db99048c2a21529c2cdc906b1
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spelling	oai:doaj.org-article:c841855db99048c2a21529c2cdc906b12021-12-02T13:57:55ZReconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds10.1038/s41467-020-20082-72041-1723https://doaj.org/article/c841855db99048c2a21529c2cdc906b12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20082-7https://doaj.org/toc/2041-1723The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tissue that supports mature T cell development in vitro and in vivo.Sara CampinotiAsllan GjinovciRoberta RagazziniLuca ZanieriLinda Ariza-McNaughtonMarco CatucciStefan BoeingJong-Eun ParkJohn C. HutchinsonMiguel Muñoz-RuizPierluigi G. MantiGianluca VozzaCarlo E. VillaDemetra-Ellie PhylactopoulosConstance MaurerGiuseppe TestaHans J. StaussSarah A. TeichmannNeil J. SebireAdrian C. HaydayDominique BonnetPaola BonfantiNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sara Campinoti Asllan Gjinovci Roberta Ragazzini Luca Zanieri Linda Ariza-McNaughton Marco Catucci Stefan Boeing Jong-Eun Park John C. Hutchinson Miguel Muñoz-Ruiz Pierluigi G. Manti Gianluca Vozza Carlo E. Villa Demetra-Ellie Phylactopoulos Constance Maurer Giuseppe Testa Hans J. Stauss Sarah A. Teichmann Neil J. Sebire Adrian C. Hayday Dominique Bonnet Paola Bonfanti Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
description	The thymus is essential for T cell maturation and selection, and thymic defects result in severe immune problems. Here the authors identify a thymus cell population that is expandable in vitro, and can repopulate natural thymic matrix to generate tissue that supports mature T cell development in vitro and in vivo.
format	article
author	Sara Campinoti Asllan Gjinovci Roberta Ragazzini Luca Zanieri Linda Ariza-McNaughton Marco Catucci Stefan Boeing Jong-Eun Park John C. Hutchinson Miguel Muñoz-Ruiz Pierluigi G. Manti Gianluca Vozza Carlo E. Villa Demetra-Ellie Phylactopoulos Constance Maurer Giuseppe Testa Hans J. Stauss Sarah A. Teichmann Neil J. Sebire Adrian C. Hayday Dominique Bonnet Paola Bonfanti
author_facet	Sara Campinoti Asllan Gjinovci Roberta Ragazzini Luca Zanieri Linda Ariza-McNaughton Marco Catucci Stefan Boeing Jong-Eun Park John C. Hutchinson Miguel Muñoz-Ruiz Pierluigi G. Manti Gianluca Vozza Carlo E. Villa Demetra-Ellie Phylactopoulos Constance Maurer Giuseppe Testa Hans J. Stauss Sarah A. Teichmann Neil J. Sebire Adrian C. Hayday Dominique Bonnet Paola Bonfanti
author_sort	Sara Campinoti
title	Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
title_short	Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
title_full	Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
title_fullStr	Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
title_full_unstemmed	Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
title_sort	reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c841855db99048c2a21529c2cdc906b1
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Reconstitution of a functional human thymus by postnatal stromal progenitor cells and natural whole-organ scaffolds

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