Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model
Disease-modifying therapies, such as neuroprotective and neurorestorative interventions, are strongly desired for Alzheimer’s disease (AD) treatment. Several studies have suggested that histone deacetylase 2 (HDAC2) inhibition can exhibit disease-modifying effects in AD patients. However, whether HD...
Guardado en:
Autores principales: | Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/c841b9aef81c4ced98bd22dc7a9a7458 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Plaque-Associated Oligomeric Amyloid-Beta Drives Early Synaptotoxicity in APP/PS1 Mice Hippocampus: Ultrastructural Pathology Analysis
por: Raquel Sanchez-Varo, et al.
Publicado: (2021) -
Τhe Greek Variant in APP Gene: The Phenotypic Spectrum of APP Mutations
por: Stefania Kalampokini, et al.
Publicado: (2021) -
Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
por: Tiwari S, et al.
Publicado: (2019) -
Mutations, associated with early-onset Alzheimer’s disease, discovered in Asian countries
por: Bagyinszky E, et al.
Publicado: (2016) -
Epigenetic mechanisms underlying the effects of triptolide and tripchlorolide on the expression of neuroligin-1 in the hippocampus of APP/PS1 transgenic mice
por: Xiaomei Lu, et al.
Publicado: (2019)