Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

Disease-modifying therapies, such as neuroprotective and neurorestorative interventions, are strongly desired for Alzheimer’s disease (AD) treatment. Several studies have suggested that histone deacetylase 2 (HDAC2) inhibition can exhibit disease-modifying effects in AD patients. However, whether HD...

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Autores principales:	Daiki Nakatsuka, Takaya Izumi, Tasuku Tsukamoto, Miki Oyama, Kohei Nishitomi, Yuichi Deguchi, Kazuki Niidome, Hidekuni Yamakawa, Hisanori Ito, Koichi Ogawa
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HDAC2 Alzheimer’s disease dendritic morphology double transgenic mice amyloid precursor protein learning and memory Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/c841b9aef81c4ced98bd22dc7a9a7458
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Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

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