Targeted removal of epigenetic barriers during transcriptional reprogramming

Master transcription factors dominantly direct cell fate and barriers ensuring their tissue specific silencing are not clearly defined. Here, the authors demonstrate that inefficient targeted transactivation of Sox1 in neural progenitor cells is surmountable through targeted promoter demethylation u...

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Autores principales:	Valentin Baumann, Maximilian Wiesbeck, Christopher T. Breunig, Julia M. Braun, Anna Köferle, Jovica Ninkovic, Magdalena Götz, Stefan H. Stricker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c84676bceefe4d2ea9650ddd58251fa5
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spelling	oai:doaj.org-article:c84676bceefe4d2ea9650ddd58251fa52021-12-02T14:38:37ZTargeted removal of epigenetic barriers during transcriptional reprogramming10.1038/s41467-019-10146-82041-1723https://doaj.org/article/c84676bceefe4d2ea9650ddd58251fa52019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10146-8https://doaj.org/toc/2041-1723Master transcription factors dominantly direct cell fate and barriers ensuring their tissue specific silencing are not clearly defined. Here, the authors demonstrate that inefficient targeted transactivation of Sox1 in neural progenitor cells is surmountable through targeted promoter demethylation using dCas9-Tet1.Valentin BaumannMaximilian WiesbeckChristopher T. BreunigJulia M. BraunAnna KöferleJovica NinkovicMagdalena GötzStefan H. StrickerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Valentin Baumann Maximilian Wiesbeck Christopher T. Breunig Julia M. Braun Anna Köferle Jovica Ninkovic Magdalena Götz Stefan H. Stricker Targeted removal of epigenetic barriers during transcriptional reprogramming
description	Master transcription factors dominantly direct cell fate and barriers ensuring their tissue specific silencing are not clearly defined. Here, the authors demonstrate that inefficient targeted transactivation of Sox1 in neural progenitor cells is surmountable through targeted promoter demethylation using dCas9-Tet1.
format	article
author	Valentin Baumann Maximilian Wiesbeck Christopher T. Breunig Julia M. Braun Anna Köferle Jovica Ninkovic Magdalena Götz Stefan H. Stricker
author_facet	Valentin Baumann Maximilian Wiesbeck Christopher T. Breunig Julia M. Braun Anna Köferle Jovica Ninkovic Magdalena Götz Stefan H. Stricker
author_sort	Valentin Baumann
title	Targeted removal of epigenetic barriers during transcriptional reprogramming
title_short	Targeted removal of epigenetic barriers during transcriptional reprogramming
title_full	Targeted removal of epigenetic barriers during transcriptional reprogramming
title_fullStr	Targeted removal of epigenetic barriers during transcriptional reprogramming
title_full_unstemmed	Targeted removal of epigenetic barriers during transcriptional reprogramming
title_sort	targeted removal of epigenetic barriers during transcriptional reprogramming
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c84676bceefe4d2ea9650ddd58251fa5
work_keys_str_mv	AT valentinbaumann targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT maximilianwiesbeck targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT christophertbreunig targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT juliambraun targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT annakoferle targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT jovicaninkovic targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT magdalenagotz targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming AT stefanhstricker targetedremovalofepigeneticbarriersduringtranscriptionalreprogramming
_version_	1718390978511896576

Targeted removal of epigenetic barriers during transcriptional reprogramming

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