A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad pr...
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Nature Portfolio
2020
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oai:doaj.org-article:c846bd63ad3c41699aff8d93671d6bf12021-12-02T13:57:55ZA therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite10.1038/s41467-020-19981-62041-1723https://doaj.org/article/c846bd63ad3c41699aff8d93671d6bf12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19981-6https://doaj.org/toc/2041-1723Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad protection in experimental animals against the lethal effects of snakebites from multiple snake species.Laura-Oana AlbulescuChunfang XieStuart AinsworthJaffer AlsolaissEdouard CrittendenCharlotte A. DawsonRowan SoftleyKeirah E. BartlettRobert A. HarrisonJeroen KoolNicholas R. CasewellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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Science Q Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
description |
Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad protection in experimental animals against the lethal effects of snakebites from multiple snake species. |
format |
article |
author |
Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell |
author_facet |
Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell |
author_sort |
Laura-Oana Albulescu |
title |
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
title_short |
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
title_full |
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
title_fullStr |
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
title_full_unstemmed |
A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
title_sort |
therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/c846bd63ad3c41699aff8d93671d6bf1 |
work_keys_str_mv |
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