A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad pr...

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Auteurs principaux:	Laura-Oana Albulescu, Chunfang Xie, Stuart Ainsworth, Jaffer Alsolaiss, Edouard Crittenden, Charlotte A. Dawson, Rowan Softley, Keirah E. Bartlett, Robert A. Harrison, Jeroen Kool, Nicholas R. Casewell
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2020
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c846bd63ad3c41699aff8d93671d6bf1
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spelling	oai:doaj.org-article:c846bd63ad3c41699aff8d93671d6bf12021-12-02T13:57:55ZA therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite10.1038/s41467-020-19981-62041-1723https://doaj.org/article/c846bd63ad3c41699aff8d93671d6bf12020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19981-6https://doaj.org/toc/2041-1723Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad protection in experimental animals against the lethal effects of snakebites from multiple snake species.Laura-Oana AlbulescuChunfang XieStuart AinsworthJaffer AlsolaissEdouard CrittendenCharlotte A. DawsonRowan SoftleyKeirah E. BartlettRobert A. HarrisonJeroen KoolNicholas R. CasewellNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
description	Snakebite is a life-threatening neglected tropical disease that is currently treated using different antibody-based antivenoms, each effective against bites of specific snake species, but not others. Here, the authors show that a combination of two toxin-inhibiting repurposed drugs provides broad protection in experimental animals against the lethal effects of snakebites from multiple snake species.
format	article
author	Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell
author_facet	Laura-Oana Albulescu Chunfang Xie Stuart Ainsworth Jaffer Alsolaiss Edouard Crittenden Charlotte A. Dawson Rowan Softley Keirah E. Bartlett Robert A. Harrison Jeroen Kool Nicholas R. Casewell
author_sort	Laura-Oana Albulescu
title	A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
title_short	A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
title_full	A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
title_fullStr	A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
title_full_unstemmed	A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
title_sort	therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c846bd63ad3c41699aff8d93671d6bf1
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A therapeutic combination of two small molecule toxin inhibitors provides broad preclinical efficacy against viper snakebite

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