Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

Malate dehydrogenase (MDH) is one of the key enzymes for succinic acid (SA) bioproduction. Here, the authors report biochemical and structural analyses of various MDHs to reveal amino acids influencing the specific activity and susceptibility to substrate inhibition, and achieve industrial-level SA...

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Autores principales: Jung Ho Ahn, Hogyun Seo, Woojin Park, Jihye Seok, Jong An Lee, Won Jun Kim, Gi Bae Kim, Kyung-Jin Kim, Sang Yup Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c8473773cdfe4e9cbfe7eeeede635aca
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Sumario:Malate dehydrogenase (MDH) is one of the key enzymes for succinic acid (SA) bioproduction. Here, the authors report biochemical and structural analyses of various MDHs to reveal amino acids influencing the specific activity and susceptibility to substrate inhibition, and achieve industrial-level SA production.