Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

Malate dehydrogenase (MDH) is one of the key enzymes for succinic acid (SA) bioproduction. Here, the authors report biochemical and structural analyses of various MDHs to reveal amino acids influencing the specific activity and susceptibility to substrate inhibition, and achieve industrial-level SA...

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Autores principales: Jung Ho Ahn, Hogyun Seo, Woojin Park, Jihye Seok, Jong An Lee, Won Jun Kim, Gi Bae Kim, Kyung-Jin Kim, Sang Yup Lee
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c8473773cdfe4e9cbfe7eeeede635aca
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spelling oai:doaj.org-article:c8473773cdfe4e9cbfe7eeeede635aca2021-12-02T14:40:52ZEnhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase10.1038/s41467-020-15839-z2041-1723https://doaj.org/article/c8473773cdfe4e9cbfe7eeeede635aca2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15839-zhttps://doaj.org/toc/2041-1723Malate dehydrogenase (MDH) is one of the key enzymes for succinic acid (SA) bioproduction. Here, the authors report biochemical and structural analyses of various MDHs to reveal amino acids influencing the specific activity and susceptibility to substrate inhibition, and achieve industrial-level SA production.Jung Ho AhnHogyun SeoWoojin ParkJihye SeokJong An LeeWon Jun KimGi Bae KimKyung-Jin KimSang Yup LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jung Ho Ahn
Hogyun Seo
Woojin Park
Jihye Seok
Jong An Lee
Won Jun Kim
Gi Bae Kim
Kyung-Jin Kim
Sang Yup Lee
Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
description Malate dehydrogenase (MDH) is one of the key enzymes for succinic acid (SA) bioproduction. Here, the authors report biochemical and structural analyses of various MDHs to reveal amino acids influencing the specific activity and susceptibility to substrate inhibition, and achieve industrial-level SA production.
format article
author Jung Ho Ahn
Hogyun Seo
Woojin Park
Jihye Seok
Jong An Lee
Won Jun Kim
Gi Bae Kim
Kyung-Jin Kim
Sang Yup Lee
author_facet Jung Ho Ahn
Hogyun Seo
Woojin Park
Jihye Seok
Jong An Lee
Won Jun Kim
Gi Bae Kim
Kyung-Jin Kim
Sang Yup Lee
author_sort Jung Ho Ahn
title Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
title_short Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
title_full Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
title_fullStr Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
title_full_unstemmed Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase
title_sort enhanced succinic acid production by mannheimia employing optimal malate dehydrogenase
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c8473773cdfe4e9cbfe7eeeede635aca
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