Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology,...

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Autores principales:	Qing Y, Cheng L, Li R, Liu G, Zhang Y, Tang X, Wang J, Liu H, Qin Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Antibacterial mechanism Biocompatibility Osteogenic related cells Orthopedic implants Silver nanoparticles Surface modification Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c848d0942321499d8da44ee3838b123f
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spelling	oai:doaj.org-article:c848d0942321499d8da44ee3838b123f2021-12-02T00:05:17ZPotential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies1178-2013https://doaj.org/article/c848d0942321499d8da44ee3838b123f2018-06-01T00:00:00Zhttps://www.dovepress.com/potential-antibacterial-mechanism-of-silver-nanoparticles-and-the-opti-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized. Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modificationQing YCheng LLi RLiu GZhang YTang XWang JLiu HQin YDove Medical PressarticleAntibacterial mechanismBiocompatibilityOsteogenic related cellsOrthopedic implantsSilver nanoparticlesSurface modificationMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 3311-3327 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antibacterial mechanism Biocompatibility Osteogenic related cells Orthopedic implants Silver nanoparticles Surface modification Medicine (General) R5-920
spellingShingle	Antibacterial mechanism Biocompatibility Osteogenic related cells Orthopedic implants Silver nanoparticles Surface modification Medicine (General) R5-920 Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
description	Yun’an Qing,1 Lin Cheng,2 Ruiyan Li,1 Guancong Liu,1 Yanbo Zhang,1 Xiongfeng Tang,1 Jincheng Wang,1 He Liu,1 Yanguo Qin1 1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun 130041, People’s Republic of China Abstract: Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized. Keywords: antibacterial mechanism, biocompatibility, osteogenic-related cells, orthopedic implants, silver nanoparticles, surface modification
format	article
author	Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y
author_facet	Qing Y Cheng L Li R Liu G Zhang Y Tang X Wang J Liu H Qin Y
author_sort	Qing Y
title	Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
title_short	Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
title_full	Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
title_fullStr	Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
title_full_unstemmed	Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
title_sort	potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/c848d0942321499d8da44ee3838b123f
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Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced modification technologies

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