TIGIT limits immune pathology during viral infections

TIGIT limits immune pathology during viral infections

TIGIT is a lymphocyte co-inhibitory receptor that can limit type 1 and cytotoxic T cell responses and maintain immunological tolerance. Here the authors show that TIGIT also limits immune pathology during LCMV or influenza infections in mice by driving IL-10 expression without negatively affecting t...

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Autores principales: Michelle Schorer, Nikolas Rakebrandt, Katharina Lambert, Annika Hunziker, Katharina Pallmer, Annette Oxenius, Anja Kipar, Silke Stertz, Nicole Joller
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/c8492053acd54e879e004b10fac09bc3
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spelling oai:doaj.org-article:c8492053acd54e879e004b10fac09bc32021-12-02T14:42:49ZTIGIT limits immune pathology during viral infections10.1038/s41467-020-15025-12041-1723https://doaj.org/article/c8492053acd54e879e004b10fac09bc32020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15025-1https://doaj.org/toc/2041-1723TIGIT is a lymphocyte co-inhibitory receptor that can limit type 1 and cytotoxic T cell responses and maintain immunological tolerance. Here the authors show that TIGIT also limits immune pathology during LCMV or influenza infections in mice by driving IL-10 expression without negatively affecting the viral load.Michelle SchorerNikolas RakebrandtKatharina LambertAnnika HunzikerKatharina PallmerAnnette OxeniusAnja KiparSilke StertzNicole JollerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Michelle Schorer
Nikolas Rakebrandt
Katharina Lambert
Annika Hunziker
Katharina Pallmer
Annette Oxenius
Anja Kipar
Silke Stertz
Nicole Joller
TIGIT limits immune pathology during viral infections
description TIGIT is a lymphocyte co-inhibitory receptor that can limit type 1 and cytotoxic T cell responses and maintain immunological tolerance. Here the authors show that TIGIT also limits immune pathology during LCMV or influenza infections in mice by driving IL-10 expression without negatively affecting the viral load.
format article
author Michelle Schorer
Nikolas Rakebrandt
Katharina Lambert
Annika Hunziker
Katharina Pallmer
Annette Oxenius
Anja Kipar
Silke Stertz
Nicole Joller
author_facet Michelle Schorer
Nikolas Rakebrandt
Katharina Lambert
Annika Hunziker
Katharina Pallmer
Annette Oxenius
Anja Kipar
Silke Stertz
Nicole Joller
author_sort Michelle Schorer
title TIGIT limits immune pathology during viral infections
title_short TIGIT limits immune pathology during viral infections
title_full TIGIT limits immune pathology during viral infections
title_fullStr TIGIT limits immune pathology during viral infections
title_full_unstemmed TIGIT limits immune pathology during viral infections
title_sort tigit limits immune pathology during viral infections
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/c8492053acd54e879e004b10fac09bc3
work_keys_str_mv AT michelleschorer tigitlimitsimmunepathologyduringviralinfections
AT nikolasrakebrandt tigitlimitsimmunepathologyduringviralinfections
AT katharinalambert tigitlimitsimmunepathologyduringviralinfections
AT annikahunziker tigitlimitsimmunepathologyduringviralinfections
AT katharinapallmer tigitlimitsimmunepathologyduringviralinfections
AT annetteoxenius tigitlimitsimmunepathologyduringviralinfections
AT anjakipar tigitlimitsimmunepathologyduringviralinfections
AT silkestertz tigitlimitsimmunepathologyduringviralinfections
AT nicolejoller tigitlimitsimmunepathologyduringviralinfections
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