TIGIT limits immune pathology during viral infections

TIGIT is a lymphocyte co-inhibitory receptor that can limit type 1 and cytotoxic T cell responses and maintain immunological tolerance. Here the authors show that TIGIT also limits immune pathology during LCMV or influenza infections in mice by driving IL-10 expression without negatively affecting t...

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Auteurs principaux: Michelle Schorer, Nikolas Rakebrandt, Katharina Lambert, Annika Hunziker, Katharina Pallmer, Annette Oxenius, Anja Kipar, Silke Stertz, Nicole Joller
Format: article
Langue:EN
Publié: Nature Portfolio 2020
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Accès en ligne:https://doaj.org/article/c8492053acd54e879e004b10fac09bc3
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