Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population

Feng-ling Xu, Jun Yao, Xue Wu, Xi Xia, Jia-xin Xing, Jin-feng Xuan, Yong-ping Liu, Bao-jie Wang School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of ChinaCorrespondence: Bao-jie WangSchool of Forensic Medicine, China Medical University, No. 77 Puhe R...

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Autores principales:	Xu F, Yao J, Wu X, Xia X, Xing J, Xuan J, Liu Y, Wang B
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	rgs4 schizophrenia promoter region snps Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c84ae32554ac4dd980ecd30b7c75e4b4
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spelling	oai:doaj.org-article:c84ae32554ac4dd980ecd30b7c75e4b42021-12-02T11:37:59ZAssociation Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population1178-2021https://doaj.org/article/c84ae32554ac4dd980ecd30b7c75e4b42020-04-01T00:00:00Zhttps://www.dovepress.com/association-analysis-between-snps-in-the-promoter-region-of-rgs4-and-s-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Feng-ling Xu, Jun Yao, Xue Wu, Xi Xia, Jia-xin Xing, Jin-feng Xuan, Yong-ping Liu, Bao-jie Wang School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of ChinaCorrespondence: Bao-jie WangSchool of Forensic Medicine, China Medical University, No. 77 Puhe Road, Shenbei New District, Shenyang 110122, People’s Republic of ChinaEmail wangbj77@163.comBackground: Abnormal RGS4 gene expression may cause neurotransmitter disorders, resulting in schizophrenia. The association between RGS4 and the risk of schizophrenia is controversial, and there has been little research on the SNPs in the promoter region of RGS4.Purpose: The present study was performed to detect the association between SNPs in the promoter region of the RGS4 gene and the risk of schizophrenia.Materials and Methods: In this study, the 1757-bp fragment (− 1119–+600, TSS+1) of RGS4 was amplified and sequenced in 198 schizophrenia patients and 264 healthy controls of the northern Chinese Han population. Allele, genotype and haplotype frequencies were analyzed by chi‐square test.Results: Four SNPs were detected in the region. LD analysis determined that rs7515900 was linked to rs10917671 (D’ = 1, r2 = 1). Therefore, the data for rs10917671 were eliminated from further analysis. Genotype TT of rs12041948 (P = 0.009, OR = 1.829, and 95% CI = 0.038– 0.766) was significantly different between the two groups in the northern Chinese Han population. In males, genotype GG of rs6678136 (P = 0.009, OR = 2.292, and 95% CI = 1.256– 4.18) and CC of rs7515900 (P = 0.003, OR = 2.523, and 95% CI = 1.332– 4.778) were significantly different.Conclusion: The results of this study suggested that genotype TT of rs12041948 in the pooled male and female samples and GG of rs6678136 and CC of rs7515900 in the male samples could be risk factors for schizophrenia. The present study is the first to detect an association between SNPs in the promoter region of the RGS4 gene and the risk of schizophrenia in the northern Chinese Han population. Functional studies are required to confirm these findings.Keywords: RGS4, schizophrenia, promoter region, SNPsXu FYao JWu XXia XXing JXuan JLiu YWang BDove Medical Pressarticlergs4schizophreniapromoter regionsnpsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 985-992 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rgs4 schizophrenia promoter region snps Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	rgs4 schizophrenia promoter region snps Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu F Yao J Wu X Xia X Xing J Xuan J Liu Y Wang B Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
description	Feng-ling Xu, Jun Yao, Xue Wu, Xi Xia, Jia-xin Xing, Jin-feng Xuan, Yong-ping Liu, Bao-jie Wang School of Forensic Medicine, China Medical University, Shenyang 110122, People’s Republic of ChinaCorrespondence: Bao-jie WangSchool of Forensic Medicine, China Medical University, No. 77 Puhe Road, Shenbei New District, Shenyang 110122, People’s Republic of ChinaEmail wangbj77@163.comBackground: Abnormal RGS4 gene expression may cause neurotransmitter disorders, resulting in schizophrenia. The association between RGS4 and the risk of schizophrenia is controversial, and there has been little research on the SNPs in the promoter region of RGS4.Purpose: The present study was performed to detect the association between SNPs in the promoter region of the RGS4 gene and the risk of schizophrenia.Materials and Methods: In this study, the 1757-bp fragment (− 1119–+600, TSS+1) of RGS4 was amplified and sequenced in 198 schizophrenia patients and 264 healthy controls of the northern Chinese Han population. Allele, genotype and haplotype frequencies were analyzed by chi‐square test.Results: Four SNPs were detected in the region. LD analysis determined that rs7515900 was linked to rs10917671 (D’ = 1, r2 = 1). Therefore, the data for rs10917671 were eliminated from further analysis. Genotype TT of rs12041948 (P = 0.009, OR = 1.829, and 95% CI = 0.038– 0.766) was significantly different between the two groups in the northern Chinese Han population. In males, genotype GG of rs6678136 (P = 0.009, OR = 2.292, and 95% CI = 1.256– 4.18) and CC of rs7515900 (P = 0.003, OR = 2.523, and 95% CI = 1.332– 4.778) were significantly different.Conclusion: The results of this study suggested that genotype TT of rs12041948 in the pooled male and female samples and GG of rs6678136 and CC of rs7515900 in the male samples could be risk factors for schizophrenia. The present study is the first to detect an association between SNPs in the promoter region of the RGS4 gene and the risk of schizophrenia in the northern Chinese Han population. Functional studies are required to confirm these findings.Keywords: RGS4, schizophrenia, promoter region, SNPs
format	article
author	Xu F Yao J Wu X Xia X Xing J Xuan J Liu Y Wang B
author_facet	Xu F Yao J Wu X Xia X Xing J Xuan J Liu Y Wang B
author_sort	Xu F
title	Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
title_short	Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
title_full	Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
title_fullStr	Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
title_full_unstemmed	Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population
title_sort	association analysis between snps in the promoter region of rgs4 and schizophrenia in the northern chinese han population
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c84ae32554ac4dd980ecd30b7c75e4b4
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Association Analysis Between SNPs in the Promoter Region of RGS4 and Schizophrenia in the Northern Chinese Han Population

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