IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes t...

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Autores principales:	Qingxiao Song, Xiaoning Wang, Xiwei Wu, Tae Hyuk Kang, Hanjun Qin, Dongchang Zhao, Robert R. Jenq, Marcel R. M. van den Brink, Arthur D. Riggs, Paul J. Martin, Yuan-Zhong Chen, Defu Zeng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c8534a9423bb4707be4f40f6e27c3f2e
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spelling	oai:doaj.org-article:c8534a9423bb4707be4f40f6e27c3f2e2021-12-02T14:06:16ZIL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice10.1038/s41467-021-21133-32041-1723https://doaj.org/article/c8534a9423bb4707be4f40f6e27c3f2e2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21133-3https://doaj.org/toc/2041-1723Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes to SR-Gut-aGVHD onset.Qingxiao SongXiaoning WangXiwei WuTae Hyuk KangHanjun QinDongchang ZhaoRobert R. JenqMarcel R. M. van den BrinkArthur D. RiggsPaul J. MartinYuan-Zhong ChenDefu ZengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qingxiao Song Xiaoning Wang Xiwei Wu Tae Hyuk Kang Hanjun Qin Dongchang Zhao Robert R. Jenq Marcel R. M. van den Brink Arthur D. Riggs Paul J. Martin Yuan-Zhong Chen Defu Zeng IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
description	Pathogenesis of steroid-resistant gut acute graft-versus-host-disease (SR-Gut-aGVHD) remains unclear., Here the authors show in mouse models that dysbiosis caused by the expansion of Th/Tc22, as well as depletion of CX3CR1hi mononuclear phagocytes resulted from the reduction of Th/Tc1, contributes to SR-Gut-aGVHD onset.
format	article
author	Qingxiao Song Xiaoning Wang Xiwei Wu Tae Hyuk Kang Hanjun Qin Dongchang Zhao Robert R. Jenq Marcel R. M. van den Brink Arthur D. Riggs Paul J. Martin Yuan-Zhong Chen Defu Zeng
author_facet	Qingxiao Song Xiaoning Wang Xiwei Wu Tae Hyuk Kang Hanjun Qin Dongchang Zhao Robert R. Jenq Marcel R. M. van den Brink Arthur D. Riggs Paul J. Martin Yuan-Zhong Chen Defu Zeng
author_sort	Qingxiao Song
title	IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
title_short	IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
title_full	IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
title_fullStr	IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
title_full_unstemmed	IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
title_sort	il-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8534a9423bb4707be4f40f6e27c3f2e
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IL-22-dependent dysbiosis and mononuclear phagocyte depletion contribute to steroid-resistant gut graft-versus-host disease in mice

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