VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS

The immunomodulatory activity of vascular endothelial growth factors (VEGFs) reveals a new role of neoangiogenesis in tumor development. Most of VEGF effects on T cells are mediated through the VEGF-R2 receptors. Placental growth factor (PlGF) belongs to the VEGFs family and is a selective ligand fo...

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Auteurs principaux:	E. R. Chernykh, O. Yu. Leplina, M. A. Tikhonova, E. V. Batorov, A. A. Ostanin
Format:	article
Langue:	RU
Publié:	SPb RAACI 2019
Sujets:	vegf vegf-r1 plgf т cells immunosupression Immunologic diseases. Allergy RC581-607
Accès en ligne:	https://doaj.org/article/c85851d822a14a219263bda43e1b113b
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spelling	oai:doaj.org-article:c85851d822a14a219263bda43e1b113b2021-11-18T08:03:48ZVASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS1563-06252313-741X10.15789/1563-0625-2019-4-653-660https://doaj.org/article/c85851d822a14a219263bda43e1b113b2019-10-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1715https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XThe immunomodulatory activity of vascular endothelial growth factors (VEGFs) reveals a new role of neoangiogenesis in tumor development. Most of VEGF effects on T cells are mediated through the VEGF-R2 receptors. Placental growth factor (PlGF) belongs to the VEGFs family and is a selective ligand for VEGF-R1. In order to study the role of VEGF-R1-signaling in the regulation of T-cell functions, the effect of PlGF on the proliferation of donor T cell has been investigated. PlGF has been shown to inhibit the proliferation of T-lymphocytes in cultures of anti-CD3-stimulated mononuclear cells in a wide dose range, suppressing the proliferative response of both CD4 + and CD8 + T cells. The suppressive effect of PlGF was mediated through the direct interaction with VEGFR-1 on T-cells that was evidenced by the expression of VEGFR-1 by T-lymphocytes (especially after their activation) and by blocking the suppressive effect of PlGF with neutralizing anti-VEGFR-1 antibodies. Given the increased levels of PlGF in many tumors, this factor may play an important role in immunomodulation during tumor growth, mediating its effect through the VEGFR-1 signaling pathway.E. R. ChernykhO. Yu. LeplinaM. A. TikhonovaE. V. BatorovA. A. OstaninSPb RAACIarticlevegfvegf-r1plgfт cellsimmunosupressionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 21, Iss 4, Pp 653-660 (2019)
institution	DOAJ
collection	DOAJ
language	RU
topic	vegf vegf-r1 plgf т cells immunosupression Immunologic diseases. Allergy RC581-607
spellingShingle	vegf vegf-r1 plgf т cells immunosupression Immunologic diseases. Allergy RC581-607 E. R. Chernykh O. Yu. Leplina M. A. Tikhonova E. V. Batorov A. A. Ostanin VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
description	The immunomodulatory activity of vascular endothelial growth factors (VEGFs) reveals a new role of neoangiogenesis in tumor development. Most of VEGF effects on T cells are mediated through the VEGF-R2 receptors. Placental growth factor (PlGF) belongs to the VEGFs family and is a selective ligand for VEGF-R1. In order to study the role of VEGF-R1-signaling in the regulation of T-cell functions, the effect of PlGF on the proliferation of donor T cell has been investigated. PlGF has been shown to inhibit the proliferation of T-lymphocytes in cultures of anti-CD3-stimulated mononuclear cells in a wide dose range, suppressing the proliferative response of both CD4 + and CD8 + T cells. The suppressive effect of PlGF was mediated through the direct interaction with VEGFR-1 on T-cells that was evidenced by the expression of VEGFR-1 by T-lymphocytes (especially after their activation) and by blocking the suppressive effect of PlGF with neutralizing anti-VEGFR-1 antibodies. Given the increased levels of PlGF in many tumors, this factor may play an important role in immunomodulation during tumor growth, mediating its effect through the VEGFR-1 signaling pathway.
format	article
author	E. R. Chernykh O. Yu. Leplina M. A. Tikhonova E. V. Batorov A. A. Ostanin
author_facet	E. R. Chernykh O. Yu. Leplina M. A. Tikhonova E. V. Batorov A. A. Ostanin
author_sort	E. R. Chernykh
title	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
title_short	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
title_full	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
title_fullStr	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
title_full_unstemmed	VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS
title_sort	vascular endothelial growth factor receptor-1 signaling as a novel mechanism of t cell suppression in tumor neoangiogenesis
publisher	SPb RAACI
publishDate	2019
url	https://doaj.org/article/c85851d822a14a219263bda43e1b113b
work_keys_str_mv	AT erchernykh vascularendothelialgrowthfactorreceptor1signalingasanovelmechanismoftcellsuppressionintumorneoangiogenesis AT oyuleplina vascularendothelialgrowthfactorreceptor1signalingasanovelmechanismoftcellsuppressionintumorneoangiogenesis AT matikhonova vascularendothelialgrowthfactorreceptor1signalingasanovelmechanismoftcellsuppressionintumorneoangiogenesis AT evbatorov vascularendothelialgrowthfactorreceptor1signalingasanovelmechanismoftcellsuppressionintumorneoangiogenesis AT aaostanin vascularendothelialgrowthfactorreceptor1signalingasanovelmechanismoftcellsuppressionintumorneoangiogenesis
_version_	1718422381619314688

VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1 SIGNALING AS A NOVEL MECHANISM OF T CELL SUPPRESSION IN TUMOR NEOANGIOGENESIS

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