Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model

Abstract Air pollution resulting from exhaust emissions of vehicles has risen in the recent years, reportedly causing major adverse effects on the heart, lungs and the brain. Though respiratory and cardiovascular effects of these emissions are well identified, psychological and neurobiological compl...

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Autores principales:	Ankita Salvi, Gaurav Patki, Hesong Liu, Samina Salim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c85a86c4393e42059eacbbbc047bc151
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spelling	oai:doaj.org-article:c85a86c4393e42059eacbbbc047bc1512021-12-02T15:05:18ZPsychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model10.1038/s41598-017-08859-12045-2322https://doaj.org/article/c85a86c4393e42059eacbbbc047bc1512017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08859-1https://doaj.org/toc/2045-2322Abstract Air pollution resulting from exhaust emissions of vehicles has risen in the recent years, reportedly causing major adverse effects on the heart, lungs and the brain. Though respiratory and cardiovascular effects of these emissions are well identified, psychological and neurobiological complications of prolonged exposure to vehicle emissions remain unknown. Pro-oxidants are considered as major constituents of vehicle emissions. This is important considering causal link between oxidative stress and behavioral and cognitive impairments. We hypothesized that prolonged exposure to pro-oxidants in vehicle emissions result in behavioral and cognitive deficits. We developed a simulated vehicle exhaust exposure model in rats. The model used a simulated mixture of vehicle exhaust that comprised of pro-oxidant constituents of exhaust, namely, carbon dioxide (13%), carbon monoxide (0.68%) and nitrogen dioxide (1000 ppm) in air. Rats were exposed either to a high (1:10 dilution) or low (~1:1000 dilution) physiologically relevant dose of simulated mixture in air for two weeks in separate experiments followed by a comprehensive behavioral and cognitive analysis. We observed that prolonged exposure to pro-oxidants in vehicle exhaust increased anxiety-and depression-like behavior as well as led to impaired memory in rats. This is important preclinical evidence, particularly relevant to human population exposed to high vehicular traffic.Ankita SalviGaurav PatkiHesong LiuSamina SalimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ankita Salvi Gaurav Patki Hesong Liu Samina Salim Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
description	Abstract Air pollution resulting from exhaust emissions of vehicles has risen in the recent years, reportedly causing major adverse effects on the heart, lungs and the brain. Though respiratory and cardiovascular effects of these emissions are well identified, psychological and neurobiological complications of prolonged exposure to vehicle emissions remain unknown. Pro-oxidants are considered as major constituents of vehicle emissions. This is important considering causal link between oxidative stress and behavioral and cognitive impairments. We hypothesized that prolonged exposure to pro-oxidants in vehicle emissions result in behavioral and cognitive deficits. We developed a simulated vehicle exhaust exposure model in rats. The model used a simulated mixture of vehicle exhaust that comprised of pro-oxidant constituents of exhaust, namely, carbon dioxide (13%), carbon monoxide (0.68%) and nitrogen dioxide (1000 ppm) in air. Rats were exposed either to a high (1:10 dilution) or low (~1:1000 dilution) physiologically relevant dose of simulated mixture in air for two weeks in separate experiments followed by a comprehensive behavioral and cognitive analysis. We observed that prolonged exposure to pro-oxidants in vehicle exhaust increased anxiety-and depression-like behavior as well as led to impaired memory in rats. This is important preclinical evidence, particularly relevant to human population exposed to high vehicular traffic.
format	article
author	Ankita Salvi Gaurav Patki Hesong Liu Samina Salim
author_facet	Ankita Salvi Gaurav Patki Hesong Liu Samina Salim
author_sort	Ankita Salvi
title	Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
title_short	Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
title_full	Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
title_fullStr	Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
title_full_unstemmed	Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model
title_sort	psychological impact of vehicle exhaust exposure: insights from an animal model
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c85a86c4393e42059eacbbbc047bc151
work_keys_str_mv	AT ankitasalvi psychologicalimpactofvehicleexhaustexposureinsightsfromananimalmodel AT gauravpatki psychologicalimpactofvehicleexhaustexposureinsightsfromananimalmodel AT hesongliu psychologicalimpactofvehicleexhaustexposureinsightsfromananimalmodel AT saminasalim psychologicalimpactofvehicleexhaustexposureinsightsfromananimalmodel
_version_	1718388921040109568

Psychological Impact of Vehicle Exhaust Exposure: Insights from an Animal Model

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