Risk of lung cancer due to external environmental factor and epidemiological data analysis

Lung cancer is a cancer with the fastest growth in the incidence and mortality all over the world, which is an extremely serious threat to human's life and health. Evidences reveal that external environmental factors are the key drivers of lung cancer, such as smoking, radiation exposure and so...

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Autores principales:	Lingling Li, Mengyao Shao, Xingshi He, Shanjing Ren, Tianhai Tian
Formato:	article
Lenguaje:	EN
Publicado:	AIMS Press 2021
Materias:	lung cancer risk mathematical modeling radiation exposure external factor genomic instability epidemiological data Biotechnology TP248.13-248.65 Mathematics QA1-939
Acceso en línea:	https://doaj.org/article/c85b8272561146eab574f6fbbcaa3be0
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spelling	oai:doaj.org-article:c85b8272561146eab574f6fbbcaa3be02021-11-11T01:03:23ZRisk of lung cancer due to external environmental factor and epidemiological data analysis10.3934/mbe.20213041551-0018https://doaj.org/article/c85b8272561146eab574f6fbbcaa3be02021-07-01T00:00:00Zhttps://www.aimspress.com/article/doi/10.3934/mbe.2021304?viewType=HTMLhttps://doaj.org/toc/1551-0018Lung cancer is a cancer with the fastest growth in the incidence and mortality all over the world, which is an extremely serious threat to human's life and health. Evidences reveal that external environmental factors are the key drivers of lung cancer, such as smoking, radiation exposure and so on. Therefore, it is urgent to explain the mechanism of lung cancer risk due to external environmental factors experimentally and theoretically. However, it is still an open issue regarding how external environment factors affect lung cancer risk. In this paper, we summarize the main mathematical models involved the gene mutations for cancers, and review the application of the models to analyze the mechanism of lung cancer and the risk of lung cancer due to external environmental exposure. In addition, we apply the model described and the epidemiological data to analyze the influence of external environmental factors on lung cancer risk. The result indicates that radiation can cause significantly an increase in the mutation rate of cells, in particular the mutation in stability gene that leads to genomic instability. These studies not only can offer insights into the relationship between external environmental factors and human lung cancer risk, but also can provide theoretical guidance for the prevention and control of lung cancer.Lingling Li Mengyao ShaoXingshi HeShanjing RenTianhai TianAIMS Pressarticlelung cancer riskmathematical modelingradiation exposureexternal factorgenomic instabilityepidemiological dataBiotechnologyTP248.13-248.65MathematicsQA1-939ENMathematical Biosciences and Engineering, Vol 18, Iss 5, Pp 6079-6094 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lung cancer risk mathematical modeling radiation exposure external factor genomic instability epidemiological data Biotechnology TP248.13-248.65 Mathematics QA1-939
spellingShingle	lung cancer risk mathematical modeling radiation exposure external factor genomic instability epidemiological data Biotechnology TP248.13-248.65 Mathematics QA1-939 Lingling Li Mengyao Shao Xingshi He Shanjing Ren Tianhai Tian Risk of lung cancer due to external environmental factor and epidemiological data analysis
description	Lung cancer is a cancer with the fastest growth in the incidence and mortality all over the world, which is an extremely serious threat to human's life and health. Evidences reveal that external environmental factors are the key drivers of lung cancer, such as smoking, radiation exposure and so on. Therefore, it is urgent to explain the mechanism of lung cancer risk due to external environmental factors experimentally and theoretically. However, it is still an open issue regarding how external environment factors affect lung cancer risk. In this paper, we summarize the main mathematical models involved the gene mutations for cancers, and review the application of the models to analyze the mechanism of lung cancer and the risk of lung cancer due to external environmental exposure. In addition, we apply the model described and the epidemiological data to analyze the influence of external environmental factors on lung cancer risk. The result indicates that radiation can cause significantly an increase in the mutation rate of cells, in particular the mutation in stability gene that leads to genomic instability. These studies not only can offer insights into the relationship between external environmental factors and human lung cancer risk, but also can provide theoretical guidance for the prevention and control of lung cancer.
format	article
author	Lingling Li Mengyao Shao Xingshi He Shanjing Ren Tianhai Tian
author_facet	Lingling Li Mengyao Shao Xingshi He Shanjing Ren Tianhai Tian
author_sort	Lingling Li
title	Risk of lung cancer due to external environmental factor and epidemiological data analysis
title_short	Risk of lung cancer due to external environmental factor and epidemiological data analysis
title_full	Risk of lung cancer due to external environmental factor and epidemiological data analysis
title_fullStr	Risk of lung cancer due to external environmental factor and epidemiological data analysis
title_full_unstemmed	Risk of lung cancer due to external environmental factor and epidemiological data analysis
title_sort	risk of lung cancer due to external environmental factor and epidemiological data analysis
publisher	AIMS Press
publishDate	2021
url	https://doaj.org/article/c85b8272561146eab574f6fbbcaa3be0
work_keys_str_mv	AT linglingli riskoflungcancerduetoexternalenvironmentalfactorandepidemiologicaldataanalysis AT mengyaoshao riskoflungcancerduetoexternalenvironmentalfactorandepidemiologicaldataanalysis AT xingshihe riskoflungcancerduetoexternalenvironmentalfactorandepidemiologicaldataanalysis AT shanjingren riskoflungcancerduetoexternalenvironmentalfactorandepidemiologicaldataanalysis AT tianhaitian riskoflungcancerduetoexternalenvironmentalfactorandepidemiologicaldataanalysis
_version_	1718439626967875584

Risk of lung cancer due to external environmental factor and epidemiological data analysis

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