Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry
The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging mass cytometry in pre-clinical mouse models.
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Nature Portfolio
2021
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oai:doaj.org-article:c85c11c742864408a99b5e94e13e53db2021-12-02T18:37:16ZCharacterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry10.1038/s41467-021-26214-x2041-1723https://doaj.org/article/c85c11c742864408a99b5e94e13e53db2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26214-xhttps://doaj.org/toc/2041-1723The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging mass cytometry in pre-clinical mouse models.Febe van MaldegemKarishma ValandMegan ColeHarshil PatelMihaela AngelovaSareena RanaEmma ColliverKatey EnfieldNourdine BahGavin KellyVictoria Siu Kwan TsangEdurne MugarzaChristopher MoorePhilip HobsonDina LeviMiriam Molina-ArcasCharles SwantonJulian DownwardNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Febe van Maldegem Karishma Valand Megan Cole Harshil Patel Mihaela Angelova Sareena Rana Emma Colliver Katey Enfield Nourdine Bah Gavin Kelly Victoria Siu Kwan Tsang Edurne Mugarza Christopher Moore Philip Hobson Dina Levi Miriam Molina-Arcas Charles Swanton Julian Downward Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| description |
The tumour microenvironment (TME) may change in response to cancer treatments such as KRAS G12C inhibition, with potential implications for combination therapies. Here, the authors provide an antibody panel and workflow for analysing the TME with imaging mass cytometry in pre-clinical mouse models. |
| format |
article |
| author |
Febe van Maldegem Karishma Valand Megan Cole Harshil Patel Mihaela Angelova Sareena Rana Emma Colliver Katey Enfield Nourdine Bah Gavin Kelly Victoria Siu Kwan Tsang Edurne Mugarza Christopher Moore Philip Hobson Dina Levi Miriam Molina-Arcas Charles Swanton Julian Downward |
| author_facet |
Febe van Maldegem Karishma Valand Megan Cole Harshil Patel Mihaela Angelova Sareena Rana Emma Colliver Katey Enfield Nourdine Bah Gavin Kelly Victoria Siu Kwan Tsang Edurne Mugarza Christopher Moore Philip Hobson Dina Levi Miriam Molina-Arcas Charles Swanton Julian Downward |
| author_sort |
Febe van Maldegem |
| title |
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| title_short |
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| title_full |
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| title_fullStr |
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| title_full_unstemmed |
Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| title_sort |
characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c85c11c742864408a99b5e94e13e53db |
| work_keys_str_mv |
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1718377826001879040 |