Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts

The use of traditional chemical insecticides for pest control often leads to environmental pollution and a decrease in biodiversity. Recently, insect sex pheromones were applied for sustainable biocontrol of pests in fields, due to their limited adverse impacts on biodiversity and food safety compar...

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Autores principales:	Xiaoling Zhang, Qin Miao, Xia Xu, Boyang Ji, Lingbo Qu, Yongjun Wei
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	insect sex pheromone fatty acids Saccharomyces cerevisiae metabolic engineering synthetic biology Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/c85c240bb93c4ca895d4e14590441bd7
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spelling	oai:doaj.org-article:c85c240bb93c4ca895d4e14590441bd72021-11-11T09:56:24ZDevelopments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts1664-302X10.3389/fmicb.2021.759975https://doaj.org/article/c85c240bb93c4ca895d4e14590441bd72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.759975/fullhttps://doaj.org/toc/1664-302XThe use of traditional chemical insecticides for pest control often leads to environmental pollution and a decrease in biodiversity. Recently, insect sex pheromones were applied for sustainable biocontrol of pests in fields, due to their limited adverse impacts on biodiversity and food safety compared to that of other conventional insecticides. However, the structures of insect pheromones are complex, and their chemical synthesis is not commercially feasible. As yeasts have been widely used for fatty acid-derived pheromone production in the past few years, using engineered yeasts may be promising and sustainable for the low-cost production of fatty acid-derived pheromones. The primary fatty acids produced by Saccharomyces cerevisiae and other yeasts are C16 and C18, and it is also possible to rewire/reprogram the metabolic flux for other fatty acids or fatty acid derivatives. This review summarizes the fatty acid biosynthetic pathway in S. cerevisiae and recent progress in yeast engineering in terms of metabolic engineering and synthetic biology strategies to produce insect pheromones. In the future, insect pheromones produced by yeasts might provide an eco-friendly pest control method in agricultural fields.Xiaoling ZhangXiaoling ZhangQin MiaoQin MiaoXia XuBoyang JiLingbo QuLingbo QuYongjun WeiYongjun WeiFrontiers Media S.A.articleinsect sex pheromonefatty acidsSaccharomyces cerevisiaemetabolic engineeringsynthetic biologyMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	insect sex pheromone fatty acids Saccharomyces cerevisiae metabolic engineering synthetic biology Microbiology QR1-502
spellingShingle	insect sex pheromone fatty acids Saccharomyces cerevisiae metabolic engineering synthetic biology Microbiology QR1-502 Xiaoling Zhang Xiaoling Zhang Qin Miao Qin Miao Xia Xu Boyang Ji Lingbo Qu Lingbo Qu Yongjun Wei Yongjun Wei Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
description	The use of traditional chemical insecticides for pest control often leads to environmental pollution and a decrease in biodiversity. Recently, insect sex pheromones were applied for sustainable biocontrol of pests in fields, due to their limited adverse impacts on biodiversity and food safety compared to that of other conventional insecticides. However, the structures of insect pheromones are complex, and their chemical synthesis is not commercially feasible. As yeasts have been widely used for fatty acid-derived pheromone production in the past few years, using engineered yeasts may be promising and sustainable for the low-cost production of fatty acid-derived pheromones. The primary fatty acids produced by Saccharomyces cerevisiae and other yeasts are C16 and C18, and it is also possible to rewire/reprogram the metabolic flux for other fatty acids or fatty acid derivatives. This review summarizes the fatty acid biosynthetic pathway in S. cerevisiae and recent progress in yeast engineering in terms of metabolic engineering and synthetic biology strategies to produce insect pheromones. In the future, insect pheromones produced by yeasts might provide an eco-friendly pest control method in agricultural fields.
format	article
author	Xiaoling Zhang Xiaoling Zhang Qin Miao Qin Miao Xia Xu Boyang Ji Lingbo Qu Lingbo Qu Yongjun Wei Yongjun Wei
author_facet	Xiaoling Zhang Xiaoling Zhang Qin Miao Qin Miao Xia Xu Boyang Ji Lingbo Qu Lingbo Qu Yongjun Wei Yongjun Wei
author_sort	Xiaoling Zhang
title	Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
title_short	Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
title_full	Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
title_fullStr	Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
title_full_unstemmed	Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts
title_sort	developments in fatty acid-derived insect pheromone production using engineered yeasts
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/c85c240bb93c4ca895d4e14590441bd7
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Developments in Fatty Acid-Derived Insect Pheromone Production Using Engineered Yeasts

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