Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

Stress kinases are activated in peripheral ischemic tissues in the presence of vascular diseases. Here the authors show that inhibition of the neural JNK3 kinase improves recovery from hind limb ischemia in animals through activation of the transcription factors Egr1/Creb1 and upregulation of growth...

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Autores principales:	Shashi Kant, Siobhan M. Craige, Kai Chen, Michaella M. Reif, Heather Learnard, Mark Kelly, Amada D. Caliz, Khanh-Van Tran, Kasmir Ramo, Owen M. Peters, Marc Freeman, Roger J. Davis, John F. Keaney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c85d0f19e33747f1a03502a4c952220b
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spelling	oai:doaj.org-article:c85d0f19e33747f1a03502a4c952220b2021-12-02T14:38:45ZNeural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis10.1038/s41467-019-11982-42041-1723https://doaj.org/article/c85d0f19e33747f1a03502a4c952220b2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11982-4https://doaj.org/toc/2041-1723Stress kinases are activated in peripheral ischemic tissues in the presence of vascular diseases. Here the authors show that inhibition of the neural JNK3 kinase improves recovery from hind limb ischemia in animals through activation of the transcription factors Egr1/Creb1 and upregulation of growth factors.Shashi KantSiobhan M. CraigeKai ChenMichaella M. ReifHeather LearnardMark KellyAmada D. CalizKhanh-Van TranKasmir RamoOwen M. PetersMarc FreemanRoger J. DavisJohn F. KeaneyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shashi Kant Siobhan M. Craige Kai Chen Michaella M. Reif Heather Learnard Mark Kelly Amada D. Caliz Khanh-Van Tran Kasmir Ramo Owen M. Peters Marc Freeman Roger J. Davis John F. Keaney Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
description	Stress kinases are activated in peripheral ischemic tissues in the presence of vascular diseases. Here the authors show that inhibition of the neural JNK3 kinase improves recovery from hind limb ischemia in animals through activation of the transcription factors Egr1/Creb1 and upregulation of growth factors.
format	article
author	Shashi Kant Siobhan M. Craige Kai Chen Michaella M. Reif Heather Learnard Mark Kelly Amada D. Caliz Khanh-Van Tran Kasmir Ramo Owen M. Peters Marc Freeman Roger J. Davis John F. Keaney
author_facet	Shashi Kant Siobhan M. Craige Kai Chen Michaella M. Reif Heather Learnard Mark Kelly Amada D. Caliz Khanh-Van Tran Kasmir Ramo Owen M. Peters Marc Freeman Roger J. Davis John F. Keaney
author_sort	Shashi Kant
title	Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
title_short	Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
title_full	Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
title_fullStr	Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
title_full_unstemmed	Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis
title_sort	neural jnk3 regulates blood flow recovery after hindlimb ischemia in mice via an egr1/creb1 axis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/c85d0f19e33747f1a03502a4c952220b
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Neural JNK3 regulates blood flow recovery after hindlimb ischemia in mice via an Egr1/Creb1 axis

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