Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study

Chao Li,1 Xiaofen Ma,2 Mengshi Dong,2 Yi Yin,1 Kelei Hua,1 Meng Li,2 Changhong Li,2 Wenfeng Zhan,2 Cheng Li,2,3 Guihua Jiang2 1Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Med...

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Autores principales:	Li C, Ma XF, Dong MS, Yin Y, Hua KL, Li M, Li CH, Zhan WF, Jiang GH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Primary Insomnia (PI) Amplitude of low frequency fluctuations (ALFF) Resting-state fMRI Spontaneous brain activity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/c85dab39c34f4f50aa04297c5c4cb3ce
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spelling	oai:doaj.org-article:c85dab39c34f4f50aa04297c5c4cb3ce2021-12-02T02:04:40ZAbnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study1178-2021https://doaj.org/article/c85dab39c34f4f50aa04297c5c4cb3ce2016-06-01T00:00:00Zhttps://www.dovepress.com/abnormal-spontaneous-regional-brain-activity-in-primary-insomnia-a-res-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chao Li,1 Xiaofen Ma,2 Mengshi Dong,2 Yi Yin,1 Kelei Hua,1 Meng Li,2 Changhong Li,2 Wenfeng Zhan,2 Cheng Li,2,3 Guihua Jiang2 1Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, 2Department of Medical Imaging, 3Department of Renal Transplantation, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, Guangzhou, People’s Republic of China Objective: Investigating functional specialization is crucial for a complete understanding of the neural mechanisms of primary insomnia (PI). Resting-state functional magnetic resonance imaging (fMRI) is a useful tool to explore the functional specialization of PI. However, only a few studies have focused on the functional specialization of PI using resting-state fMRI and results of these studies were far from consistent. Thus, the current study aimed to investigate functional specialization of PI using resting-state fMRI with amplitude of low frequency fluctuations (ALFFs) algorithm. Methods: In this study, 55 PI patients and 44 healthy controls were included. ALFF values were compared between the two groups using two-sample t-test. The relationship of abnormal ALFF values with clinical characteristics and duration of insomnia was investigated using Pearson’s correlation analysis. Results: PI patients showed lower ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, right middle frontal gyrus, left inferior parietal lobule, and bilateral cerebellum posterior lobes, while higher ALFF values in the right middle/inferior temporal that extended to the right occipital lobe. In addition, we found that the duration of PI negatively correlated with ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, and the Pittsburgh Sleep Quality Index score negatively correlated with ALFF values in the left inferior parietal lobule. Conclusion: The present study added information to limited studies on functional specialization and provided evidence for hyperarousal hypothesis in PI. Keywords: primary insomnia, amplitude of low frequency fluctuations, resting-state fMRI, spontaneous brain activityLi CMa XFDong MSYin YHua KLLi MLi CHZhan WFLi CJiang GHDove Medical PressarticlePrimary Insomnia (PI)Amplitude of low frequency fluctuations (ALFF)Resting-state fMRISpontaneous brain activity.Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1371-1378 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Primary Insomnia (PI) Amplitude of low frequency fluctuations (ALFF) Resting-state fMRI Spontaneous brain activity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Primary Insomnia (PI) Amplitude of low frequency fluctuations (ALFF) Resting-state fMRI Spontaneous brain activity. Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li C Ma XF Dong MS Yin Y Hua KL Li M Li CH Zhan WF Li C Jiang GH Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
description	Chao Li,1 Xiaofen Ma,2 Mengshi Dong,2 Yi Yin,1 Kelei Hua,1 Meng Li,2 Changhong Li,2 Wenfeng Zhan,2 Cheng Li,2,3 Guihua Jiang2 1Department of Medical Imaging, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, The Third Clinical Medical College of Southern Medical University, 2Department of Medical Imaging, 3Department of Renal Transplantation, The Affiliated Guangdong No 2 Provincial People’s Hospital of Southern Medical University, Guangzhou, People’s Republic of China Objective: Investigating functional specialization is crucial for a complete understanding of the neural mechanisms of primary insomnia (PI). Resting-state functional magnetic resonance imaging (fMRI) is a useful tool to explore the functional specialization of PI. However, only a few studies have focused on the functional specialization of PI using resting-state fMRI and results of these studies were far from consistent. Thus, the current study aimed to investigate functional specialization of PI using resting-state fMRI with amplitude of low frequency fluctuations (ALFFs) algorithm. Methods: In this study, 55 PI patients and 44 healthy controls were included. ALFF values were compared between the two groups using two-sample t-test. The relationship of abnormal ALFF values with clinical characteristics and duration of insomnia was investigated using Pearson’s correlation analysis. Results: PI patients showed lower ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, right middle frontal gyrus, left inferior parietal lobule, and bilateral cerebellum posterior lobes, while higher ALFF values in the right middle/inferior temporal that extended to the right occipital lobe. In addition, we found that the duration of PI negatively correlated with ALFF values in the left orbitofrontal cortex/inferior frontal gyrus, and the Pittsburgh Sleep Quality Index score negatively correlated with ALFF values in the left inferior parietal lobule. Conclusion: The present study added information to limited studies on functional specialization and provided evidence for hyperarousal hypothesis in PI. Keywords: primary insomnia, amplitude of low frequency fluctuations, resting-state fMRI, spontaneous brain activity
format	article
author	Li C Ma XF Dong MS Yin Y Hua KL Li M Li CH Zhan WF Li C Jiang GH
author_facet	Li C Ma XF Dong MS Yin Y Hua KL Li M Li CH Zhan WF Li C Jiang GH
author_sort	Li C
title	Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
title_short	Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
title_full	Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
title_fullStr	Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
title_full_unstemmed	Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
title_sort	abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/c85dab39c34f4f50aa04297c5c4cb3ce
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Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study

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