Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion
Several bacteria in the gut microbiota have been associated with colorectal cancer (CRC) but it is not completely clear whether they have a role in tumourigenesis. Here, the authors show enrichment of 12 bacterial taxa in two cohorts of CRC patients and that two Porphyromonas species accelerate CRC...
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Nature Portfolio
2021
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oai:doaj.org-article:c860ece59e1d4cab983d3336301516842021-12-02T18:51:09ZGut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion10.1038/s41467-021-25965-x2041-1723https://doaj.org/article/c860ece59e1d4cab983d3336301516842021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25965-xhttps://doaj.org/toc/2041-1723Several bacteria in the gut microbiota have been associated with colorectal cancer (CRC) but it is not completely clear whether they have a role in tumourigenesis. Here, the authors show enrichment of 12 bacterial taxa in two cohorts of CRC patients and that two Porphyromonas species accelerate CRC onset through butyrate secretion.Shintaro OkumuraYusuke KonishiMegumi NarukawaYuki SugiuraShin YoshimotoYuriko AraiShintaro SatoYasuo YoshidaShunya TsujiKen UemuraMasahiro WakitaTatsuyuki MatsudairaTomonori MatsumotoShimpei KawamotoAkiko TakahashiYoshiro ItataniHiroaki MikiManabu TakamatsuKazutaka ObamaKengo TakeuchiMakoto SuematsuNaoko OhtaniYosuke FukunagaMasashi UenoYoshiharu SakaiSatoshi NagayamaEiji HaraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021) |
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DOAJ |
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EN |
| topic |
Science Q |
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Science Q Shintaro Okumura Yusuke Konishi Megumi Narukawa Yuki Sugiura Shin Yoshimoto Yuriko Arai Shintaro Sato Yasuo Yoshida Shunya Tsuji Ken Uemura Masahiro Wakita Tatsuyuki Matsudaira Tomonori Matsumoto Shimpei Kawamoto Akiko Takahashi Yoshiro Itatani Hiroaki Miki Manabu Takamatsu Kazutaka Obama Kengo Takeuchi Makoto Suematsu Naoko Ohtani Yosuke Fukunaga Masashi Ueno Yoshiharu Sakai Satoshi Nagayama Eiji Hara Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| description |
Several bacteria in the gut microbiota have been associated with colorectal cancer (CRC) but it is not completely clear whether they have a role in tumourigenesis. Here, the authors show enrichment of 12 bacterial taxa in two cohorts of CRC patients and that two Porphyromonas species accelerate CRC onset through butyrate secretion. |
| format |
article |
| author |
Shintaro Okumura Yusuke Konishi Megumi Narukawa Yuki Sugiura Shin Yoshimoto Yuriko Arai Shintaro Sato Yasuo Yoshida Shunya Tsuji Ken Uemura Masahiro Wakita Tatsuyuki Matsudaira Tomonori Matsumoto Shimpei Kawamoto Akiko Takahashi Yoshiro Itatani Hiroaki Miki Manabu Takamatsu Kazutaka Obama Kengo Takeuchi Makoto Suematsu Naoko Ohtani Yosuke Fukunaga Masashi Ueno Yoshiharu Sakai Satoshi Nagayama Eiji Hara |
| author_facet |
Shintaro Okumura Yusuke Konishi Megumi Narukawa Yuki Sugiura Shin Yoshimoto Yuriko Arai Shintaro Sato Yasuo Yoshida Shunya Tsuji Ken Uemura Masahiro Wakita Tatsuyuki Matsudaira Tomonori Matsumoto Shimpei Kawamoto Akiko Takahashi Yoshiro Itatani Hiroaki Miki Manabu Takamatsu Kazutaka Obama Kengo Takeuchi Makoto Suematsu Naoko Ohtani Yosuke Fukunaga Masashi Ueno Yoshiharu Sakai Satoshi Nagayama Eiji Hara |
| author_sort |
Shintaro Okumura |
| title |
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| title_short |
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| title_full |
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| title_fullStr |
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| title_full_unstemmed |
Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| title_sort |
gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c860ece59e1d4cab983d333630151684 |
| work_keys_str_mv |
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