Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway

QR Code

Metformin Downregulates PD-L1 Expression in Esophageal Squamous Cell Catrcinoma by Inhibiting IL-6 Signaling Pathway

PurposeTo characterize the mechanism by which metformin inhibits PD-L1 expression in esophageal squamous cell carcinoma (ESCC) and to evaluate the effect of metformin on the antitumor immune response.MethodsThe Cancer Genome Atlas (TCGA) database was used to analyze the correlations between IL-6 and...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yao Lu, Dao Xin, Lulu Guan, Mengli Xu, Yalan Yang, Yu Chen, Yuanyuan Yang, Andrea Wang-Gillam, Li Wang, Shanggang Zong, Feng Wang
Format:	article
Language:	EN
Published:	Frontiers Media S.A. 2021
Subjects:	metformin PD-L1 anti-PD-1 antibody esophageal squamous cell carcinoma IL-6/JAK2/STAT3 signaling pathway Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Online Access:	https://doaj.org/article/c861b8c7f13c4c35a4f101a9ac29c246
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses
by: Dinoop Ravindran Menon, et al.
Published: (2021)

PD-1 inhibitors versus chemotherapy as second-line treatment for advanced esophageal squamous cell carcinoma: a meta-analysis
by: Xinxin Zhu, et al.
Published: (2021)

Characterization of Esophageal Microbiota in Patients With Esophagitis and Esophageal Squamous Cell Carcinoma
by: Zongdan Jiang, et al.
Published: (2021)

Edaravone alleviates cell apoptosis and mitochondrial injury in ischemia-reperfusion-induced kidney injury via the JAK/STAT pathway
by: Zhao,Xiaoying, et al.
Published: (2020)

EFFECTS OF IL-4 UPON THE ACTIVITY OF STAT6 TRANSCRIPTION FACTOR IN PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
by: V. N. Mineev, et al.
Published: (2014)

Quantitative Proteome Analysis of <italic toggle="yes">Atg5</italic>-Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome
by: Kiran Bala Sharma, et al.
Published: (2019)

The Potential Advantage of Targeting Both PD-L1/PD-L2/PD-1 and IL-10–IL-10R Pathways in Acute Myeloid Leukemia
by: Laura Jimbu, et al.
Published: (2021)

KINETICS AND MECHANISM OF BASE HYDROLYSIS OF A-AMINOACID ESTERS CATALYSED BY [Pd(1,3- DIAMINO-2-HYDROXYPROPANE)(H2O)2]2+ COMPLEX
by: Al-QALAF,F.A, et al.
Published: (2013)

Advances and challenges in the treatment of esophageal cancer
by: Shiming He, et al.
Published: (2021)

Suppression of L-Arginine-Induced Acute Necrotizing Pancreatitis in Rats by Metformin Associated with the Inhibition of Myeloperoxidase and Activation of Interleukin-10
by: Al-Hashem,Fahaid
Published: (2021)

New Trend of Surgery in Locally Advanced Esophageal Squamous Cell Carcinoma Patients
by: Tatcha Rerkrak, et al.
Published: (2021)

STAT6 EXPRESSION BY PERIPHERAL BLOOD LYMPHOCYTES IN BRONCHIAL ASTHMA
by: V. N. Mineev, et al.
Published: (2014)

Nifuroxazide Mitigates Angiogenesis in Ehlrich’s Solid Carcinoma: Molecular Docking, Bioinformatic and Experimental Studies on Inhibition of Il-6/Jak2/Stat3 Signaling
by: Mohamed El-Sherbiny, et al.
Published: (2021)

Janus Kinase Inhibitors in the Treatment of Vitiligo: A Review
by: Fei Qi, et al.
Published: (2021)

Cost-Effectiveness Analysis of Camrelizumab Versus Chemotherapy as Second-Line Treatment of Advanced or Metastatic Esophageal Squamous Cell Carcinoma
by: Hongfu Cai, et al.
Published: (2021)

PAR1 and PAR4 exert opposite effects on tumor growth and metastasis of esophageal squamous cell carcinoma via STAT3 and NF-κB signaling pathways
by: Jia Zhao, et al.
Published: (2021)

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation
by: Han Ding, et al.
Published: (2021)

Expression and function analysis of CRABP2 and FABP5, and their ratio in esophageal squamous cell carcinoma
by: Li Mengyan, et al.
Published: (2021)

Tofacitinib Ameliorates Retinal Vascular Leakage in a Murine Model of Diabetic Retinopathy with Type 2 Diabetes
by: Eimear M. Byrne, et al.
Published: (2021)

CXCL8(3-72) K11R/G31P protects against sepsis-induced acute kidney injury via NF-κB and JAK2/STAT3 pathway
by: Zhou,Yunfeng, et al.
Published: (2019)

Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats
by: Hafez,Mohamed M, et al.
Published: (2015)

A multi‐omics study delineates new molecular features and therapeutic targets for esophageal squamous cell carcinoma
by: Xing Jin, et al.
Published: (2021)

Current Progress and Future Perspectives of Immune Checkpoint in Cancer and Infectious Diseases
by: Xin Cai, et al.
Published: (2021)

3D Organoids: An Untapped Platform for Studying Host–Microbiome Interactions in Esophageal Cancers
by: Samuel Flashner, et al.
Published: (2021)

Immunoexpression of PD-L1 and PD-1 and Its Clinicopathological Correlation in Urothelial Carcinomas
by: Utpal Kumar, et al.
Published: (2021)

Relation Between Tumor Budding and Endoscopic Classification, Degree of Malignancy in T1 Stage Esophageal Squamous Cell Carcinoma
by: WANG Kang, et al.
Published: (2021)

Esophageal stent placement as a therapeutic option for iatrogenic esophageal perforation in children
by: Alsafadi Ahmad, et al.
Published: (2016)

Expression analysis of protein inhibitor of activated STAT (PIAS) genes in IFNβ-treated multiple sclerosis patients
by: Taheri M, et al.
Published: (2018)

New Insights into the Role of PD-1 and Its Ligands in Allergic Disease
by: Miguel Angel Galván Morales, et al.
Published: (2021)

IL6R inhibits viability and apoptosis of pancreatic beta-cells in type 2 diabetes mellitus via regulation by miR-22 of the JAK/STAT signaling pathway
by: Wu X, et al.
Published: (2019)

Clinicoprognostic and Histopathological Features of Guttate and Plaque Psoriasis Based on PD-1 Expression
by: Chang-Jin Jung, et al.
Published: (2021)

Treatment-Related Adverse Events with PD-1 or PD-L1 Inhibitors: A Systematic Review and Meta-Analysis
by: Yixi Zhang, et al.
Published: (2021)

A Novel Autophagy-Related Long Non-Coding RNA Signature to Predict Prognosis and Therapeutic Response in Esophageal Squamous Cell Carcinoma
by: Shi X, et al.
Published: (2021)

Activated Natural Killer Cell Promotes Nonalcoholic Steatohepatitis Through Mediating JAK/STAT PathwaySummary
by: Feixue Wang, et al.
Published: (2022)

Combination of Endoscopic Resection and Radiofrequency Ablation for the Treatment of Esophageal Squamous Cell Neoplasia With Multiple Lugol-Voiding Lesions
by: Zhihao Chen, et al.
Published: (2021)

Corrigendum: ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway
by: Yu-Li Shen, et al.
Published: (2021)

Overexpression of miR125b Promotes Osteoporosis Through miR-125b-TRAF6 Pathway in Postmenopausal Ovariectomized Rats
by: Wang G, et al.
Published: (2021)

Predictive Value of Baseline [18F]FDG PET/CT for Response to Systemic Therapy in Patients with Advanced Melanoma
by: Virginia Liberini, et al.
Published: (2021)

Programmed death‐ligand 1 expression in swine chronic infections and enhancement of interleukin‐2 production via programmed death‐1/programmed death‐ligand 1 blockade
by: Otgontuya Ganbaatar, et al.
Published: (2021)

Overexpression of E3 ubiquitin ligase Cbl attenuates endothelial dysfunction in diabetes mellitus by inhibiting the JAK2/STAT4 signaling and Runx3-mediated H3K4me3
by: Qingsong Jin, et al.
Published: (2021)