The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks

Arsenic trioxide (ATO) has confirmed as a global pollutant, the toxic effect of which was not fully understood and lack effective therapies to against its associated toxicities. Curcumin (Cur) is a beneficial natural pigment for its antioxidant and anti-inflammatory properties. The purpose of this p...

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Autores principales:	Shaofeng Wu, Gan Rao, Rui Wang, Qiling Pang, Xiaoyong Zhang, Riming Huang, Taotao Li, Zhaoxin Tang, Lianmei Hu
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Arsenic trioxide Curcumin Brain Oxidative stress Inflammatory Nrf2 Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/c863eb6c458d4fb7a0f1e94c9e852a9c
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spelling	oai:doaj.org-article:c863eb6c458d4fb7a0f1e94c9e852a9c2021-11-14T04:28:20ZThe neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks0147-651310.1016/j.ecoenv.2021.112965https://doaj.org/article/c863eb6c458d4fb7a0f1e94c9e852a9c2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321010770https://doaj.org/toc/0147-6513Arsenic trioxide (ATO) has confirmed as a global pollutant, the toxic effect of which was not fully understood and lack effective therapies to against its associated toxicities. Curcumin (Cur) is a beneficial natural pigment for its antioxidant and anti-inflammatory properties. The purpose of this paper was to illustrate the antagonism of Cur against ATO-induced neurotoxicity. A total of 40 ducks were divided randomly into 4 groups and conducted via bite and sup for 28 days: control group (Control); 2 mg/kg ATO group (Low ATO); 4 mg/kg ATO group (Middle ATO); 8 mg/kg ATO group (High ATO); 400 mg/kg Cur group + 8 mg/kg ATO (Cur+ATO). The results showed that ATO exposure can hinder the duck growth and arsenic element accumulation rate increased in a dose-dependent manner. We observed neuronal shrinkage and vacuolize of HE staining in the ATO-treated group. In addition, SOD activity and T-AOC level reduced while MDA content increased in the ATO-exposed group. ATO exposure can decrease the expression of anti-oxidation related mRNA and proteins (Nrf2, SOD-1, GPX-1, CAT, Trx and HO-1) and anti-inflammatory makers (IL-4, IL-10), increased the expression of Keap1, NF-κB and pro-inflammatory makers (TNF-α, IL-1β, IL-18, IL-2, IL-6, INOS and COX-2). ATO treated might cause blood-brain barrier (BBB) damage through degradation of the tight junction proteins (TJs) occludin and ZO-1. Importantly, the experimental results also showed that Cur can alleviate oxidative stress, inflammatory response and BBB injury caused by ATO exposure through Nrf2 and NF-κB signaling pathway. The results suggested Cur exerted as a food additive and provided novel potential benefits of ATO toxicology in inflammation of the brain.Shaofeng WuGan RaoRui WangQiling PangXiaoyong ZhangRiming HuangTaotao LiZhaoxin TangLianmei HuElsevierarticleArsenic trioxideCurcuminBrainOxidative stressInflammatoryNrf2Environmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112965- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arsenic trioxide Curcumin Brain Oxidative stress Inflammatory Nrf2 Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Arsenic trioxide Curcumin Brain Oxidative stress Inflammatory Nrf2 Environmental pollution TD172-193.5 Environmental sciences GE1-350 Shaofeng Wu Gan Rao Rui Wang Qiling Pang Xiaoyong Zhang Riming Huang Taotao Li Zhaoxin Tang Lianmei Hu The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
description	Arsenic trioxide (ATO) has confirmed as a global pollutant, the toxic effect of which was not fully understood and lack effective therapies to against its associated toxicities. Curcumin (Cur) is a beneficial natural pigment for its antioxidant and anti-inflammatory properties. The purpose of this paper was to illustrate the antagonism of Cur against ATO-induced neurotoxicity. A total of 40 ducks were divided randomly into 4 groups and conducted via bite and sup for 28 days: control group (Control); 2 mg/kg ATO group (Low ATO); 4 mg/kg ATO group (Middle ATO); 8 mg/kg ATO group (High ATO); 400 mg/kg Cur group + 8 mg/kg ATO (Cur+ATO). The results showed that ATO exposure can hinder the duck growth and arsenic element accumulation rate increased in a dose-dependent manner. We observed neuronal shrinkage and vacuolize of HE staining in the ATO-treated group. In addition, SOD activity and T-AOC level reduced while MDA content increased in the ATO-exposed group. ATO exposure can decrease the expression of anti-oxidation related mRNA and proteins (Nrf2, SOD-1, GPX-1, CAT, Trx and HO-1) and anti-inflammatory makers (IL-4, IL-10), increased the expression of Keap1, NF-κB and pro-inflammatory makers (TNF-α, IL-1β, IL-18, IL-2, IL-6, INOS and COX-2). ATO treated might cause blood-brain barrier (BBB) damage through degradation of the tight junction proteins (TJs) occludin and ZO-1. Importantly, the experimental results also showed that Cur can alleviate oxidative stress, inflammatory response and BBB injury caused by ATO exposure through Nrf2 and NF-κB signaling pathway. The results suggested Cur exerted as a food additive and provided novel potential benefits of ATO toxicology in inflammation of the brain.
format	article
author	Shaofeng Wu Gan Rao Rui Wang Qiling Pang Xiaoyong Zhang Riming Huang Taotao Li Zhaoxin Tang Lianmei Hu
author_facet	Shaofeng Wu Gan Rao Rui Wang Qiling Pang Xiaoyong Zhang Riming Huang Taotao Li Zhaoxin Tang Lianmei Hu
author_sort	Shaofeng Wu
title	The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
title_short	The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
title_full	The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
title_fullStr	The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
title_full_unstemmed	The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks
title_sort	neuroprotective effect of curcumin against ato triggered neurotoxicity through nrf2 and nf-κb signaling pathway in the brain of ducks
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c863eb6c458d4fb7a0f1e94c9e852a9c
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The neuroprotective effect of curcumin against ATO triggered neurotoxicity through Nrf2 and NF-κB signaling pathway in the brain of ducks

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