The structural basis for CD36 binding by the malaria parasite

Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that is also required for lipoprotein binding.

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Autores principales:	Fu-Lien Hsieh, Louise Turner, Jani Reddy Bolla, Carol V. Robinson, Thomas Lavstsen, Matthew K. Higgins
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c868d661845e470ea603b99a9105c266
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spelling	oai:doaj.org-article:c868d661845e470ea603b99a9105c2662021-12-02T16:57:02ZThe structural basis for CD36 binding by the malaria parasite10.1038/ncomms128372041-1723https://doaj.org/article/c868d661845e470ea603b99a9105c2662016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12837https://doaj.org/toc/2041-1723Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that is also required for lipoprotein binding.Fu-Lien HsiehLouise TurnerJani Reddy BollaCarol V. RobinsonThomas LavstsenMatthew K. HigginsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fu-Lien Hsieh Louise Turner Jani Reddy Bolla Carol V. Robinson Thomas Lavstsen Matthew K. Higgins The structural basis for CD36 binding by the malaria parasite
description	Targeting of the CD36 scavenger receptor by the malaria parasite effector PfEMP1 prevents splenic clearance of infected erythrocytes. Here, the authors propose that diverse PfEMP1 achieve this by binding to a conserved phenylalanine residue in CD36 that is also required for lipoprotein binding.
format	article
author	Fu-Lien Hsieh Louise Turner Jani Reddy Bolla Carol V. Robinson Thomas Lavstsen Matthew K. Higgins
author_facet	Fu-Lien Hsieh Louise Turner Jani Reddy Bolla Carol V. Robinson Thomas Lavstsen Matthew K. Higgins
author_sort	Fu-Lien Hsieh
title	The structural basis for CD36 binding by the malaria parasite
title_short	The structural basis for CD36 binding by the malaria parasite
title_full	The structural basis for CD36 binding by the malaria parasite
title_fullStr	The structural basis for CD36 binding by the malaria parasite
title_full_unstemmed	The structural basis for CD36 binding by the malaria parasite
title_sort	structural basis for cd36 binding by the malaria parasite
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/c868d661845e470ea603b99a9105c266
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The structural basis for CD36 binding by the malaria parasite

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