Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy

Sijie Chen,1– 3 Biying Huang,1,2 Wenjing Pei,1,2 Long Wang,4 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Secon...

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Autores principales:	Chen S, Huang B, Pei W, Wang L, Xu Y, Niu C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	ir780 mitochondria-targeting perfluorocarbon photodynamic therapy photothermal therapy Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/c869469763ad49668b6aa5e59f23512f
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spelling	oai:doaj.org-article:c869469763ad49668b6aa5e59f23512f2021-12-02T15:05:10ZMitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy1178-2013https://doaj.org/article/c869469763ad49668b6aa5e59f23512f2020-11-01T00:00:00Zhttps://www.dovepress.com/mitochondria-targeting-oxygen-sufficient-perfluorocarbon-nanoparticles-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Sijie Chen,1– 3 Biying Huang,1,2 Wenjing Pei,1,2 Long Wang,4 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Department of Ultrasound Diagnosis, Changsha Central Hospital, Nanhua University, Changsha, Hunan 410014, People’s Republic of China; 4Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaEmail niuchengcheng@csu.edu.cnBackground: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.Methods and Materials: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding.Results: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect.Conclusion: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.Keywords: IR780, mitochondria-targeting, perfluorocarbon, photodynamic therapy, photothermal therapyChen SHuang BPei WWang LXu YNiu CDove Medical Pressarticleir780mitochondria-targetingperfluorocarbonphotodynamic therapyphotothermal therapyMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 8641-8658 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	ir780 mitochondria-targeting perfluorocarbon photodynamic therapy photothermal therapy Medicine (General) R5-920
spellingShingle	ir780 mitochondria-targeting perfluorocarbon photodynamic therapy photothermal therapy Medicine (General) R5-920 Chen S Huang B Pei W Wang L Xu Y Niu C Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
description	Sijie Chen,1– 3 Biying Huang,1,2 Wenjing Pei,1,2 Long Wang,4 Yan Xu,1,2 Chengcheng Niu1,2 1Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 2Research Center of Ultrasonography, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of China; 3Department of Ultrasound Diagnosis, Changsha Central Hospital, Nanhua University, Changsha, Hunan 410014, People’s Republic of China; 4Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of ChinaCorrespondence: Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, People’s Republic of ChinaEmail niuchengcheng@csu.edu.cnBackground: Although photothermal therapy (PTT) and photodynamics therapy (PDT) have both made excellent progress in tumor therapy, the effectiveness of using PTT or PDT alone is dissatisfactory due to the limitations of the penetration depth in PTT and the hypoxic microenvironment of tumors for PDT. Combination phototherapy has currently become a burgeoning cancer treatment.Methods and Materials: In this work, a mitochondria-targeting liquid perfluorocarbon (PFC)-based oxygen delivery system was developed for the synergistic PDT/photothermal therapy (PTT) of cancer through image guiding.Results: Importantly, these nanoparticles (NPs) can effectively and accurately accumulate in the target tumor via the enhanced permeability and retention (EPR) effect.Conclusion: This approach offers a novel technique to achieve outstanding antitumor efficacy by an unprecedented design with tumor mitochondria targeting, oxygen delivery, and synergistic PDT/PTT with dual-imaging guidance.Keywords: IR780, mitochondria-targeting, perfluorocarbon, photodynamic therapy, photothermal therapy
format	article
author	Chen S Huang B Pei W Wang L Xu Y Niu C
author_facet	Chen S Huang B Pei W Wang L Xu Y Niu C
author_sort	Chen S
title	Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
title_short	Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
title_full	Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
title_fullStr	Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
title_full_unstemmed	Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy
title_sort	mitochondria-targeting oxygen-sufficient perfluorocarbon nanoparticles for imaging-guided tumor phototherapy
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/c869469763ad49668b6aa5e59f23512f
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Mitochondria-Targeting Oxygen-Sufficient Perfluorocarbon Nanoparticles for Imaging-Guided Tumor Phototherapy

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