Principles underlying the complex dynamics of temperature entrainment by a circadian clock

Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rh...

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Autores principales:	Philipp Burt, Saskia Grabe, Cornelia Madeti, Abhishek Upadhyay, Martha Merrow, Till Roenneberg, Hanspeter Herzel, Christoph Schmal
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chronobiology Systems biology In silico biology Plant biology Science Q
Acceso en línea:	https://doaj.org/article/c86cdd7fecb0449e9b4cd82d3a3dd946
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spelling	oai:doaj.org-article:c86cdd7fecb0449e9b4cd82d3a3dd9462021-11-20T05:10:46ZPrinciples underlying the complex dynamics of temperature entrainment by a circadian clock2589-004210.1016/j.isci.2021.103370https://doaj.org/article/c86cdd7fecb0449e9b4cd82d3a3dd9462021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013419https://doaj.org/toc/2589-0042Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.Philipp BurtSaskia GrabeCornelia MadetiAbhishek UpadhyayMartha MerrowTill RoennebergHanspeter HerzelChristoph SchmalElsevierarticleChronobiologySystems biologyIn silico biologyPlant biologyScienceQENiScience, Vol 24, Iss 11, Pp 103370- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronobiology Systems biology In silico biology Plant biology Science Q
spellingShingle	Chronobiology Systems biology In silico biology Plant biology Science Q Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal Principles underlying the complex dynamics of temperature entrainment by a circadian clock
description	Summary: Autonomously oscillating circadian clocks resonate with daily environmental (zeitgeber) rhythms to organize physiology around the solar day. Although entrainment properties and mechanisms have been studied widely and in great detail for light-dark cycles, entrainment to daily temperature rhythms remains poorly understood despite that they are potent zeitgebers. Here we investigate the entrainment of the chronobiological model organism Neurospora crassa, subject to thermocycles of different periods and fractions of warm versus cold phases, mimicking seasonal variations. Depending on the properties of these thermocycles, regularly entrained rhythms, period-doubling (frequency demultiplication) but also irregular aperiodic behavior occurs. We demonstrate that the complex nonlinear phenomena of experimentally observed entrainment dynamics can be understood by molecular mathematical modeling.
format	article
author	Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal
author_facet	Philipp Burt Saskia Grabe Cornelia Madeti Abhishek Upadhyay Martha Merrow Till Roenneberg Hanspeter Herzel Christoph Schmal
author_sort	Philipp Burt
title	Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_short	Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_full	Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_fullStr	Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_full_unstemmed	Principles underlying the complex dynamics of temperature entrainment by a circadian clock
title_sort	principles underlying the complex dynamics of temperature entrainment by a circadian clock
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c86cdd7fecb0449e9b4cd82d3a3dd946
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Principles underlying the complex dynamics of temperature entrainment by a circadian clock

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