Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions

Summary: Emerging evidence suggests that ADP-ribosylation factor like-4c (Arl4c) may be a potential choice for cancer treatment. However, its role in pancreatic cancer, especially in tumor-stroma interactions and drug resistance, is still unknown. In the current study, we examined the proliferation...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xin Chen, Yanzhen Zhang, Weikun Qian, Liang Han, Wei Li, Wanxing Duan, Zheng Wu, Zheng Wang, Qingyong Ma
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Biological sciences Cell biology Functional aspects of cell biology Cancer Science Q
Acceso en línea:	https://doaj.org/article/c870e6ed27ce479db65dfcc739daa263
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c870e6ed27ce479db65dfcc739daa263
record_format	dspace
spelling	oai:doaj.org-article:c870e6ed27ce479db65dfcc739daa2632021-11-22T04:28:31ZArl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions2589-004210.1016/j.isci.2021.103400https://doaj.org/article/c870e6ed27ce479db65dfcc739daa2632021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221013717https://doaj.org/toc/2589-0042Summary: Emerging evidence suggests that ADP-ribosylation factor like-4c (Arl4c) may be a potential choice for cancer treatment. However, its role in pancreatic cancer, especially in tumor-stroma interactions and drug resistance, is still unknown. In the current study, we examined the proliferation and drug resistance effect of Arl4c on pancreatic cancer cells. Furthermore, we explored the contribution of Arl4c high expression in pancreatic stellate cell (PSC) activation. We found that high Arl4c expression is associated with cell proliferation, drug resistance, and PSC activation. In detail, Arl4c regulates connective tissue growth factor (CTGF) paracrine, further induces autophagic flux in PSCs, resulting in PSC activation. TGFβ1 secreted by activated PSCs enhances cancer cell stem cell properties via smad2 signaling, further increasing cell drug resistance. YAP is an important mediator of the Arl4c-CTGF loop. Taken together, these results suggest that Arl4c is essential for pancreatic cancer progression and may be an effective therapeutic choice.Xin ChenYanzhen ZhangWeikun QianLiang HanWei LiWanxing DuanZheng WuZheng WangQingyong MaElsevierarticleBiological sciencesCell biologyFunctional aspects of cell biologyCancerScienceQENiScience, Vol 24, Iss 12, Pp 103400- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biological sciences Cell biology Functional aspects of cell biology Cancer Science Q
spellingShingle	Biological sciences Cell biology Functional aspects of cell biology Cancer Science Q Xin Chen Yanzhen Zhang Weikun Qian Liang Han Wei Li Wanxing Duan Zheng Wu Zheng Wang Qingyong Ma Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
description	Summary: Emerging evidence suggests that ADP-ribosylation factor like-4c (Arl4c) may be a potential choice for cancer treatment. However, its role in pancreatic cancer, especially in tumor-stroma interactions and drug resistance, is still unknown. In the current study, we examined the proliferation and drug resistance effect of Arl4c on pancreatic cancer cells. Furthermore, we explored the contribution of Arl4c high expression in pancreatic stellate cell (PSC) activation. We found that high Arl4c expression is associated with cell proliferation, drug resistance, and PSC activation. In detail, Arl4c regulates connective tissue growth factor (CTGF) paracrine, further induces autophagic flux in PSCs, resulting in PSC activation. TGFβ1 secreted by activated PSCs enhances cancer cell stem cell properties via smad2 signaling, further increasing cell drug resistance. YAP is an important mediator of the Arl4c-CTGF loop. Taken together, these results suggest that Arl4c is essential for pancreatic cancer progression and may be an effective therapeutic choice.
format	article
author	Xin Chen Yanzhen Zhang Weikun Qian Liang Han Wei Li Wanxing Duan Zheng Wu Zheng Wang Qingyong Ma
author_facet	Xin Chen Yanzhen Zhang Weikun Qian Liang Han Wei Li Wanxing Duan Zheng Wu Zheng Wang Qingyong Ma
author_sort	Xin Chen
title	Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
title_short	Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
title_full	Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
title_fullStr	Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
title_full_unstemmed	Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
title_sort	arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/c870e6ed27ce479db65dfcc739daa263
work_keys_str_mv	AT xinchen arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT yanzhenzhang arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT weikunqian arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT lianghan arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT weili arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT wanxingduan arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT zhengwu arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT zhengwang arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions AT qingyongma arl4cpromotesthegrowthanddrugresistanceofpancreaticcancerbyregulatingtumorstromalinteractions
_version_	1718418186160832512

Arl4c promotes the growth and drug resistance of pancreatic cancer by regulating tumor-stromal interactions

Ejemplares similares