The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.

<h4>Background</h4>Congenital prosopagnosia (CP) describes an impairment in face processing that is presumably present from birth. The neuronal correlates of this dysfunction are still under debate. In the current paper, we investigate high-frequent oscillatory activity in response to fa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Christian Dobel, Markus Junghöfer, Thomas Gruber
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c872c38586324d149bcf7455d0c43aaa
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c872c38586324d149bcf7455d0c43aaa
record_format	dspace
spelling	oai:doaj.org-article:c872c38586324d149bcf7455d0c43aaa2021-11-18T06:54:25ZThe role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.1932-620310.1371/journal.pone.0019550https://doaj.org/article/c872c38586324d149bcf7455d0c43aaa2011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21573175/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Congenital prosopagnosia (CP) describes an impairment in face processing that is presumably present from birth. The neuronal correlates of this dysfunction are still under debate. In the current paper, we investigate high-frequent oscillatory activity in response to faces in persons with CP. Such neuronal activity is thought to reflect higher-level representations for faces.<h4>Methodology</h4>Source localization of induced Gamma-Band Responses (iGBR) measured by magnetoencephalography (MEG) was used to establish the origin of oscillatory activity in response to famous and unknown faces which were presented in upright and inverted orientation. Persons suffering from congenital prosopagnosia (CP) were compared to matched controls.<h4>Principal findings</h4>Corroborating earlier research, both groups revealed amplified iGBR in response to upright compared to inverted faces predominately in a time interval between 170 and 330 ms and in a frequency range from 50-100 Hz. Oscillatory activity upon known faces was smaller in comparison to unknown faces, suggesting a "sharpening" effect reflecting more efficient processing for familiar stimuli. These effects were seen in a wide cortical network encompassing temporal and parietal areas involved in the disambiguation of homogenous stimuli such as faces, and in the retrieval of semantic information. Importantly, participants suffering from CP displayed a strongly reduced iGBR in the left fusiform area compared to control participants.<h4>Conclusions</h4>In sum, these data stress the crucial role of oscillatory activity for face representation and demonstrate the involvement of a distributed occipito-temporo-parietal network in generating iGBR. This study also provides the first evidence that persons suffering from an agnosia actually display reduced gamma band activity. Finally, the results argue strongly against the view that oscillatory activity is a mere epiphenomenon brought fourth by rapid eye-movements (micro saccades).Christian DobelMarkus JunghöferThomas GruberPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19550 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christian Dobel Markus Junghöfer Thomas Gruber The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
description	<h4>Background</h4>Congenital prosopagnosia (CP) describes an impairment in face processing that is presumably present from birth. The neuronal correlates of this dysfunction are still under debate. In the current paper, we investigate high-frequent oscillatory activity in response to faces in persons with CP. Such neuronal activity is thought to reflect higher-level representations for faces.<h4>Methodology</h4>Source localization of induced Gamma-Band Responses (iGBR) measured by magnetoencephalography (MEG) was used to establish the origin of oscillatory activity in response to famous and unknown faces which were presented in upright and inverted orientation. Persons suffering from congenital prosopagnosia (CP) were compared to matched controls.<h4>Principal findings</h4>Corroborating earlier research, both groups revealed amplified iGBR in response to upright compared to inverted faces predominately in a time interval between 170 and 330 ms and in a frequency range from 50-100 Hz. Oscillatory activity upon known faces was smaller in comparison to unknown faces, suggesting a "sharpening" effect reflecting more efficient processing for familiar stimuli. These effects were seen in a wide cortical network encompassing temporal and parietal areas involved in the disambiguation of homogenous stimuli such as faces, and in the retrieval of semantic information. Importantly, participants suffering from CP displayed a strongly reduced iGBR in the left fusiform area compared to control participants.<h4>Conclusions</h4>In sum, these data stress the crucial role of oscillatory activity for face representation and demonstrate the involvement of a distributed occipito-temporo-parietal network in generating iGBR. This study also provides the first evidence that persons suffering from an agnosia actually display reduced gamma band activity. Finally, the results argue strongly against the view that oscillatory activity is a mere epiphenomenon brought fourth by rapid eye-movements (micro saccades).
format	article
author	Christian Dobel Markus Junghöfer Thomas Gruber
author_facet	Christian Dobel Markus Junghöfer Thomas Gruber
author_sort	Christian Dobel
title	The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
title_short	The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
title_full	The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
title_fullStr	The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
title_full_unstemmed	The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
title_sort	role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/c872c38586324d149bcf7455d0c43aaa
work_keys_str_mv	AT christiandobel theroleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia AT markusjunghofer theroleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia AT thomasgruber theroleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia AT christiandobel roleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia AT markusjunghofer roleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia AT thomasgruber roleofgammabandactivityintherepresentationoffacesreducedactivityinthefusiformfaceareaincongenitalprosopagnosia
_version_	1718424255510609920

The role of gamma-band activity in the representation of faces: reduced activity in the fusiform face area in congenital prosopagnosia.

Ejemplares similares