The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population

Abstract Development of coronary artery disease (CAD) is primarily due to the process of atherosclerosis, however the prognosis of CAD depends on pleiotropic effects of the genes located at 9p21.3 region. Genome wide association studies revealed association of variants in this region with CAD pathol...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Gorre Manjula, Rayabarapu Pranavchand, Irgam Kumuda, B. Sriteja Reddy, Battini Mohan Reddy
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8733a33320d4a5b9c0b2a94b6f417ec
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:c8733a33320d4a5b9c0b2a94b6f417ec
record_format	dspace
spelling	oai:doaj.org-article:c8733a33320d4a5b9c0b2a94b6f417ec2021-12-02T16:18:02ZThe SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population10.1038/s41598-020-77080-42045-2322https://doaj.org/article/c8733a33320d4a5b9c0b2a94b6f417ec2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77080-4https://doaj.org/toc/2045-2322Abstract Development of coronary artery disease (CAD) is primarily due to the process of atherosclerosis, however the prognosis of CAD depends on pleiotropic effects of the genes located at 9p21.3 region. Genome wide association studies revealed association of variants in this region with CAD pathology. However, specific marker in predicting CAD development or progression is not yet identified. In the present study, 35 SNPs at 9p21.3 region, located in the cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) genes, were genotyped among 350 CAD cases and 480 controls from the southern Indian population of Hyderabad using fluidigm nanofluidic SNP genotyping system and the data were analyzed using PLINK and R softwares. Of the 35 SNPs analysed, only one SNP, rs7865618, was found to be highly significantly associated with CAD, even after correction for multiple testing (p = 0.008). The AG and GG genotypes of this SNP conferred 3.08 and 1.93 folds increased risk for CAD respectively. In particular, this SNP was significantly associated with severe anatomic (triple vessel disease p = 0.023) and phenotypic (acute coronary syndrome p = 0.007) categories of CAD. Pair wise SNP interaction analysis between the SNPs of 9p21.3 and 11q23.3 regions revealed significantly increased risk of three SNPs of 11q23.3 region that were not associated individually, in conjunction with rs7865618 of 9p21.3.Gorre ManjulaRayabarapu PranavchandIrgam KumudaB. Sriteja ReddyBattini Mohan ReddyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gorre Manjula Rayabarapu Pranavchand Irgam Kumuda B. Sriteja Reddy Battini Mohan Reddy The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
description	Abstract Development of coronary artery disease (CAD) is primarily due to the process of atherosclerosis, however the prognosis of CAD depends on pleiotropic effects of the genes located at 9p21.3 region. Genome wide association studies revealed association of variants in this region with CAD pathology. However, specific marker in predicting CAD development or progression is not yet identified. In the present study, 35 SNPs at 9p21.3 region, located in the cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) genes, were genotyped among 350 CAD cases and 480 controls from the southern Indian population of Hyderabad using fluidigm nanofluidic SNP genotyping system and the data were analyzed using PLINK and R softwares. Of the 35 SNPs analysed, only one SNP, rs7865618, was found to be highly significantly associated with CAD, even after correction for multiple testing (p = 0.008). The AG and GG genotypes of this SNP conferred 3.08 and 1.93 folds increased risk for CAD respectively. In particular, this SNP was significantly associated with severe anatomic (triple vessel disease p = 0.023) and phenotypic (acute coronary syndrome p = 0.007) categories of CAD. Pair wise SNP interaction analysis between the SNPs of 9p21.3 and 11q23.3 regions revealed significantly increased risk of three SNPs of 11q23.3 region that were not associated individually, in conjunction with rs7865618 of 9p21.3.
format	article
author	Gorre Manjula Rayabarapu Pranavchand Irgam Kumuda B. Sriteja Reddy Battini Mohan Reddy
author_facet	Gorre Manjula Rayabarapu Pranavchand Irgam Kumuda B. Sriteja Reddy Battini Mohan Reddy
author_sort	Gorre Manjula
title	The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
title_short	The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
title_full	The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
title_fullStr	The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
title_full_unstemmed	The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population
title_sort	snp rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern indian population
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/c8733a33320d4a5b9c0b2a94b6f417ec
work_keys_str_mv	AT gorremanjula thesnprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT rayabarapupranavchand thesnprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT irgamkumuda thesnprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT bsritejareddy thesnprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT battinimohanreddy thesnprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT gorremanjula snprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT rayabarapupranavchand snprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT irgamkumuda snprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT bsritejareddy snprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation AT battinimohanreddy snprs7865618of9p213locusemergesasthemostpromisingmarkerofcoronaryarterydiseaseinthesouthernindianpopulation
_version_	1718384255193579520

The SNP rs7865618 of 9p21.3 locus emerges as the most promising marker of coronary artery disease in the southern Indian population

Ejemplares similares