Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
Carbapenemase-producing <i>Enterobacterales,</i> including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i> were isolated from a patient...
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| Autores principales: | , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/c873d361dc094ffa89309bbf6eaeef20 |
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| Sumario: | Carbapenemase-producing <i>Enterobacterales,</i> including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i> were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with <i>bla</i>KPC-2 on a Tn<i>4401b</i> element. Both strains also carried IncP1 plasmids, but that of <i>C. farmeri</i> did not carry a Beta-lactamase gene, whereas that of <i>K. michiganensis</i> carried a second copy of <i>bla</i><sub>KPC-2</sub> on Tn<i>4401b</i>. These results suggest recent plasmid transfer between the two species and a recent transposition event. |
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