Complete Genome Sequences of Klebsiella michiganensis and Citrobacter farmeri, KPC-2-Producers Serially Isolated from a Single Patient

Carbapenemase-producing Enterobacterales, including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing Klebsiella michiganensis and Citrobacter farmeri were isolated from a patient...

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Autores principales:	Jehane Y. Abed, Maxime Déraspe, Ève Bérubé, Matthew D’Iorio, Ken Dewar, Maurice Boissinot, Jacques Corbeil, Michel G. Bergeron, Paul H. Roy
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Klebsiella michiganensis</i> <i>Citrobacter farmeri</i> KPC-2 carbapenemase plasmid transposon Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/c873d361dc094ffa89309bbf6eaeef20
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spelling	oai:doaj.org-article:c873d361dc094ffa89309bbf6eaeef202021-11-25T16:24:54ZComplete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient10.3390/antibiotics101114082079-6382https://doaj.org/article/c873d361dc094ffa89309bbf6eaeef202021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1408https://doaj.org/toc/2079-6382Carbapenemase-producing <i>Enterobacterales,</i> including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i> were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with <i>bla</i>KPC-2 on a Tn<i>4401b</i> element. Both strains also carried IncP1 plasmids, but that of <i>C. farmeri</i> did not carry a Beta-lactamase gene, whereas that of <i>K. michiganensis</i> carried a second copy of <i>bla</i><sub>KPC-2</sub> on Tn<i>4401b</i>. These results suggest recent plasmid transfer between the two species and a recent transposition event.Jehane Y. AbedMaxime DéraspeÈve BérubéMatthew D’IorioKen DewarMaurice BoissinotJacques CorbeilMichel G. BergeronPaul H. RoyMDPI AGarticle<i>Klebsiella michiganensis</i><i>Citrobacter farmeri</i>KPC-2carbapenemaseplasmidtransposonTherapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1408, p 1408 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Klebsiella michiganensis</i> <i>Citrobacter farmeri</i> KPC-2 carbapenemase plasmid transposon Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Klebsiella michiganensis</i> <i>Citrobacter farmeri</i> KPC-2 carbapenemase plasmid transposon Therapeutics. Pharmacology RM1-950 Jehane Y. Abed Maxime Déraspe Ève Bérubé Matthew D’Iorio Ken Dewar Maurice Boissinot Jacques Corbeil Michel G. Bergeron Paul H. Roy Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
description	Carbapenemase-producing <i>Enterobacterales,</i> including KPC-2 producers, have become a major clinical problem. During an outbreak in Quebec City, Canada, KPC-2-producing <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i> were isolated from a patient six weeks apart. We determined their complete genome sequences. Both isolates carried nearly identical IncN2 plasmids with <i>bla</i>KPC-2 on a Tn<i>4401b</i> element. Both strains also carried IncP1 plasmids, but that of <i>C. farmeri</i> did not carry a Beta-lactamase gene, whereas that of <i>K. michiganensis</i> carried a second copy of <i>bla</i><sub>KPC-2</sub> on Tn<i>4401b</i>. These results suggest recent plasmid transfer between the two species and a recent transposition event.
format	article
author	Jehane Y. Abed Maxime Déraspe Ève Bérubé Matthew D’Iorio Ken Dewar Maurice Boissinot Jacques Corbeil Michel G. Bergeron Paul H. Roy
author_facet	Jehane Y. Abed Maxime Déraspe Ève Bérubé Matthew D’Iorio Ken Dewar Maurice Boissinot Jacques Corbeil Michel G. Bergeron Paul H. Roy
author_sort	Jehane Y. Abed
title	Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
title_short	Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
title_full	Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
title_fullStr	Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
title_full_unstemmed	Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient
title_sort	complete genome sequences of <i>klebsiella michiganensis</i> and <i>citrobacter farmeri</i>, kpc-2-producers serially isolated from a single patient
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/c873d361dc094ffa89309bbf6eaeef20
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Complete Genome Sequences of <i>Klebsiella michiganensis</i> and <i>Citrobacter farmeri</i>, KPC-2-Producers Serially Isolated from a Single Patient

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