Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

Mitochondrial content in extracellular vesicles (EVs) can enhance inflammation, although its role in noninflammatory conditions is unclear. Here, the authors show that mitochondria-derived vesicles target material to EVs, whereas Parkin directs damaged mitochondrial content to lysosomes, providing i...

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Auteurs principaux:	Kiran Todkar, Lilia Chikhi, Véronique Desjardins, Firas El-Mortada, Geneviève Pépin, Marc Germain
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/c8745d1c583b43ab9f1c97bb6ad2ec3e
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spelling	oai:doaj.org-article:c8745d1c583b43ab9f1c97bb6ad2ec3e2021-12-02T18:17:51ZSelective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs10.1038/s41467-021-21984-w2041-1723https://doaj.org/article/c8745d1c583b43ab9f1c97bb6ad2ec3e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21984-whttps://doaj.org/toc/2041-1723Mitochondrial content in extracellular vesicles (EVs) can enhance inflammation, although its role in noninflammatory conditions is unclear. Here, the authors show that mitochondria-derived vesicles target material to EVs, whereas Parkin directs damaged mitochondrial content to lysosomes, providing insight into mitochondria-driven immune responses.Kiran TodkarLilia ChikhiVéronique DesjardinsFiras El-MortadaGeneviève PépinMarc GermainNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kiran Todkar Lilia Chikhi Véronique Desjardins Firas El-Mortada Geneviève Pépin Marc Germain Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
description	Mitochondrial content in extracellular vesicles (EVs) can enhance inflammation, although its role in noninflammatory conditions is unclear. Here, the authors show that mitochondria-derived vesicles target material to EVs, whereas Parkin directs damaged mitochondrial content to lysosomes, providing insight into mitochondria-driven immune responses.
format	article
author	Kiran Todkar Lilia Chikhi Véronique Desjardins Firas El-Mortada Geneviève Pépin Marc Germain
author_facet	Kiran Todkar Lilia Chikhi Véronique Desjardins Firas El-Mortada Geneviève Pépin Marc Germain
author_sort	Kiran Todkar
title	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
title_short	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
title_full	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
title_fullStr	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
title_full_unstemmed	Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs
title_sort	selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial damps
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8745d1c583b43ab9f1c97bb6ad2ec3e
work_keys_str_mv	AT kirantodkar selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps AT liliachikhi selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps AT veroniquedesjardins selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps AT firaselmortada selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps AT genevievepepin selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps AT marcgermain selectivepackagingofmitochondrialproteinsintoextracellularvesiclespreventsthereleaseofmitochondrialdamps
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Selective packaging of mitochondrial proteins into extracellular vesicles prevents the release of mitochondrial DAMPs

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