The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

The enzyme inhibitor that regenerates multiple tissues A naturally occurring small molecule shows promise as a drug for tissue and organ repair and regeneration. Viravuth Yin of the Kathryn W. Davis Center for Regenerative Biology and Medicine with colleagues in the US found that treating zebrafish...

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Autores principales:	Ashley M. Smith, Katie K. Maguire-Nguyen, Thomas A. Rando, Michael A. Zasloff, Kevin B. Strange, Viravuth P. Yin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/c8757dcf84fd49cead9c2f8b39e2e99b
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spelling	oai:doaj.org-article:c8757dcf84fd49cead9c2f8b39e2e99b2021-12-02T13:41:45ZThe protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues10.1038/s41536-017-0008-12057-3995https://doaj.org/article/c8757dcf84fd49cead9c2f8b39e2e99b2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0008-1https://doaj.org/toc/2057-3995The enzyme inhibitor that regenerates multiple tissues A naturally occurring small molecule shows promise as a drug for tissue and organ repair and regeneration. Viravuth Yin of the Kathryn W. Davis Center for Regenerative Biology and Medicine with colleagues in the US found that treating zebrafish with an intraperitoneal injection of MSI-1436, which inhibits the enzyme ‘protein tyrosine phosphatase 1B’, increased the rate of regeneration of an amputated caudal fin and of partially removed heart muscle without apparent tissue malformation. Intraperitoneal injection of MSI-1436 in adult mice also reduced the size of an induced heart infarction, improved survivability, triggered new heart muscle formation and stimulated regeneration after skeletal muscle injury. Effective doses for tissue regeneration in both animals were much lower than the maximum tolerated doses found for humans in clinical trials for potential treatment of obesity and diabetes.Ashley M. SmithKatie K. Maguire-NguyenThomas A. RandoMichael A. ZasloffKevin B. StrangeViravuth P. YinNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Ashley M. Smith Katie K. Maguire-Nguyen Thomas A. Rando Michael A. Zasloff Kevin B. Strange Viravuth P. Yin The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
description	The enzyme inhibitor that regenerates multiple tissues A naturally occurring small molecule shows promise as a drug for tissue and organ repair and regeneration. Viravuth Yin of the Kathryn W. Davis Center for Regenerative Biology and Medicine with colleagues in the US found that treating zebrafish with an intraperitoneal injection of MSI-1436, which inhibits the enzyme ‘protein tyrosine phosphatase 1B’, increased the rate of regeneration of an amputated caudal fin and of partially removed heart muscle without apparent tissue malformation. Intraperitoneal injection of MSI-1436 in adult mice also reduced the size of an induced heart infarction, improved survivability, triggered new heart muscle formation and stimulated regeneration after skeletal muscle injury. Effective doses for tissue regeneration in both animals were much lower than the maximum tolerated doses found for humans in clinical trials for potential treatment of obesity and diabetes.
format	article
author	Ashley M. Smith Katie K. Maguire-Nguyen Thomas A. Rando Michael A. Zasloff Kevin B. Strange Viravuth P. Yin
author_facet	Ashley M. Smith Katie K. Maguire-Nguyen Thomas A. Rando Michael A. Zasloff Kevin B. Strange Viravuth P. Yin
author_sort	Ashley M. Smith
title	The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
title_short	The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
title_full	The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
title_fullStr	The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
title_full_unstemmed	The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues
title_sort	protein tyrosine phosphatase 1b inhibitor msi-1436 stimulates regeneration of heart and multiple other tissues
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c8757dcf84fd49cead9c2f8b39e2e99b
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The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues

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