Cas9 targeted enrichment of mobile elements using nanopore sequencing

Mobile element insertions (MEIs) are a source of repetitive genetic variation and can lead to genetic disorders. Here the authors use Cas9-targeted nanopore sequencing to efficiently saturate enrichment for known and non-reference MEIs.

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Autores principales:	Torrin L. McDonald, Weichen Zhou, Christopher P. Castro, Camille Mumm, Jessica A. Switzenberg, Ryan E. Mills, Alan P. Boyle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c87dab68727b4dfeabb3b16502eb685a
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spelling	oai:doaj.org-article:c87dab68727b4dfeabb3b16502eb685a2021-12-02T17:52:29ZCas9 targeted enrichment of mobile elements using nanopore sequencing10.1038/s41467-021-23918-y2041-1723https://doaj.org/article/c87dab68727b4dfeabb3b16502eb685a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23918-yhttps://doaj.org/toc/2041-1723Mobile element insertions (MEIs) are a source of repetitive genetic variation and can lead to genetic disorders. Here the authors use Cas9-targeted nanopore sequencing to efficiently saturate enrichment for known and non-reference MEIs.Torrin L. McDonaldWeichen ZhouChristopher P. CastroCamille MummJessica A. SwitzenbergRyan E. MillsAlan P. BoyleNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Torrin L. McDonald Weichen Zhou Christopher P. Castro Camille Mumm Jessica A. Switzenberg Ryan E. Mills Alan P. Boyle Cas9 targeted enrichment of mobile elements using nanopore sequencing
description	Mobile element insertions (MEIs) are a source of repetitive genetic variation and can lead to genetic disorders. Here the authors use Cas9-targeted nanopore sequencing to efficiently saturate enrichment for known and non-reference MEIs.
format	article
author	Torrin L. McDonald Weichen Zhou Christopher P. Castro Camille Mumm Jessica A. Switzenberg Ryan E. Mills Alan P. Boyle
author_facet	Torrin L. McDonald Weichen Zhou Christopher P. Castro Camille Mumm Jessica A. Switzenberg Ryan E. Mills Alan P. Boyle
author_sort	Torrin L. McDonald
title	Cas9 targeted enrichment of mobile elements using nanopore sequencing
title_short	Cas9 targeted enrichment of mobile elements using nanopore sequencing
title_full	Cas9 targeted enrichment of mobile elements using nanopore sequencing
title_fullStr	Cas9 targeted enrichment of mobile elements using nanopore sequencing
title_full_unstemmed	Cas9 targeted enrichment of mobile elements using nanopore sequencing
title_sort	cas9 targeted enrichment of mobile elements using nanopore sequencing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c87dab68727b4dfeabb3b16502eb685a
work_keys_str_mv	AT torrinlmcdonald cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT weichenzhou cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT christopherpcastro cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT camillemumm cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT jessicaaswitzenberg cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT ryanemills cas9targetedenrichmentofmobileelementsusingnanoporesequencing AT alanpboyle cas9targetedenrichmentofmobileelementsusingnanoporesequencing
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Cas9 targeted enrichment of mobile elements using nanopore sequencing

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