Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

Abstract Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance w...

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Autores principales:	Sha Su, Fang Yang, Linlin Zhong, Lihong Pang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	ncRNAs Preeclampsia Biomarkers Diagnostic meta-analysis Gynecology and obstetrics RG1-991 Reproduction QH471-489
Acceso en línea:	https://doaj.org/article/c87ef53c4f98419da057e86869b05bf2
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spelling	oai:doaj.org-article:c87ef53c4f98419da057e86869b05bf22021-12-05T12:24:08ZCirculating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis10.1186/s12958-021-00852-81477-7827https://doaj.org/article/c87ef53c4f98419da057e86869b05bf22021-12-01T00:00:00Zhttps://doi.org/10.1186/s12958-021-00852-8https://doaj.org/toc/1477-7827Abstract Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0. Results A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood performed relatively well in predicting preeclampsia. The combined sensitivity was 0.71, the specificity was 0.84, and the area under the SROC curve (AUC) was 0.86. Peripheral blood mononuclear cell (PBMC) samples showed the best diagnostic accuracy. The combined AUC was 0.93. Combined detection was better than single detection, and miRNA was better than circRNA. The heterogeneity of the study was determined by sample size, lncRNA characteristics, lncRNA source and race. Conclusion Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.Sha SuFang YangLinlin ZhongLihong PangBMCarticlencRNAsPreeclampsiaBiomarkersDiagnostic meta-analysisGynecology and obstetricsRG1-991ReproductionQH471-489ENReproductive Biology and Endocrinology, Vol 19, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ncRNAs Preeclampsia Biomarkers Diagnostic meta-analysis Gynecology and obstetrics RG1-991 Reproduction QH471-489
spellingShingle	ncRNAs Preeclampsia Biomarkers Diagnostic meta-analysis Gynecology and obstetrics RG1-991 Reproduction QH471-489 Sha Su Fang Yang Linlin Zhong Lihong Pang Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
description	Abstract Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0. Results A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood performed relatively well in predicting preeclampsia. The combined sensitivity was 0.71, the specificity was 0.84, and the area under the SROC curve (AUC) was 0.86. Peripheral blood mononuclear cell (PBMC) samples showed the best diagnostic accuracy. The combined AUC was 0.93. Combined detection was better than single detection, and miRNA was better than circRNA. The heterogeneity of the study was determined by sample size, lncRNA characteristics, lncRNA source and race. Conclusion Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.
format	article
author	Sha Su Fang Yang Linlin Zhong Lihong Pang
author_facet	Sha Su Fang Yang Linlin Zhong Lihong Pang
author_sort	Sha Su
title	Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
title_short	Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
title_full	Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
title_fullStr	Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
title_full_unstemmed	Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
title_sort	circulating noncoding rnas as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis
publisher	BMC
publishDate	2021
url	https://doaj.org/article/c87ef53c4f98419da057e86869b05bf2
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Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

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