Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation

Abstract Various bioactive food compounds may confer health and longevity benefits, possibly through altering or preserving the epigenome. While bioactive food compounds are widely being marketed for human consumption as ‘improving health and longevity’ by counteracting harmful effects of poor nutri...

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Autores principales:	Erik M. K. Rasmussen, Kristine L. Seier, Ingrid K. Pedersen, Claus Kreibich, Gro V. Amdam, Daniel Münch, John Arne Dahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c882605de9904ab19a1348be6522b9b4
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spelling	oai:doaj.org-article:c882605de9904ab19a1348be6522b9b42021-12-02T19:17:05ZScreening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation10.1038/s41598-021-98614-42045-2322https://doaj.org/article/c882605de9904ab19a1348be6522b9b42021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-98614-4https://doaj.org/toc/2045-2322Abstract Various bioactive food compounds may confer health and longevity benefits, possibly through altering or preserving the epigenome. While bioactive food compounds are widely being marketed for human consumption as ‘improving health and longevity’ by counteracting harmful effects of poor nutrition and lifestyle, claimed effects are often not adequately documented. Using the honey bee (Apis mellifera) as a model species, we here employed a multi-step screening approach to investigate seven compounds for effects on lifespan and DNA methylation using ELISA and whole genome bisulfite sequencing (WGBS). A positive longevity effect was detected for valproic acid, isovaleric acid, and cyanocobalamin. For curcumin, we found that lifespan shortening caused by ethanol intake, was restored when curcumin and ethanol were co-administered. Furthermore, we identified region specific DNA methylation changes as a result of ethanol intake. Ethanol specific changes in DNA methylation were fully or partially blocked in honey bees receiving ethanol and curcumin together. Ethanol-affected and curcumin-blocked differentially methylated regions covered genes involved in fertility, temperature regulation and tubulin transport. Our results demonstrate fundamental negative effects of low dose ethanol consumption on lifespan and associated DNA methylation changes and present a proof-of-principle on how longevity and DNA methylation changes can be negated by the bioactive food component curcumin. Our findings provide a fundament for further studies of curcumin in invertebrates.Erik M. K. RasmussenKristine L. SeierIngrid K. PedersenClaus KreibichGro V. AmdamDaniel MünchJohn Arne DahlNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Erik M. K. Rasmussen Kristine L. Seier Ingrid K. Pedersen Claus Kreibich Gro V. Amdam Daniel Münch John Arne Dahl Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
description	Abstract Various bioactive food compounds may confer health and longevity benefits, possibly through altering or preserving the epigenome. While bioactive food compounds are widely being marketed for human consumption as ‘improving health and longevity’ by counteracting harmful effects of poor nutrition and lifestyle, claimed effects are often not adequately documented. Using the honey bee (Apis mellifera) as a model species, we here employed a multi-step screening approach to investigate seven compounds for effects on lifespan and DNA methylation using ELISA and whole genome bisulfite sequencing (WGBS). A positive longevity effect was detected for valproic acid, isovaleric acid, and cyanocobalamin. For curcumin, we found that lifespan shortening caused by ethanol intake, was restored when curcumin and ethanol were co-administered. Furthermore, we identified region specific DNA methylation changes as a result of ethanol intake. Ethanol specific changes in DNA methylation were fully or partially blocked in honey bees receiving ethanol and curcumin together. Ethanol-affected and curcumin-blocked differentially methylated regions covered genes involved in fertility, temperature regulation and tubulin transport. Our results demonstrate fundamental negative effects of low dose ethanol consumption on lifespan and associated DNA methylation changes and present a proof-of-principle on how longevity and DNA methylation changes can be negated by the bioactive food component curcumin. Our findings provide a fundament for further studies of curcumin in invertebrates.
format	article
author	Erik M. K. Rasmussen Kristine L. Seier Ingrid K. Pedersen Claus Kreibich Gro V. Amdam Daniel Münch John Arne Dahl
author_facet	Erik M. K. Rasmussen Kristine L. Seier Ingrid K. Pedersen Claus Kreibich Gro V. Amdam Daniel Münch John Arne Dahl
author_sort	Erik M. K. Rasmussen
title	Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
title_short	Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
title_full	Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
title_fullStr	Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
title_full_unstemmed	Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation
title_sort	screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and dna methylation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c882605de9904ab19a1348be6522b9b4
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Screening bioactive food compounds in honey bees suggests curcumin blocks alcohol-induced damage to longevity and DNA methylation

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