GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise

Abstract Body size and weight show considerable variation both within and between species. This variation is controlled in part by genetics, but also strongly influenced by environmental factors including diet and the level of activity experienced by the individual. Due to the increasing obesity epi...

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Autores principales:	Louis P. Watanabe, Nicole C. Riddle
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c8836c25027044348aed9a69ec877d4a
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spelling	oai:doaj.org-article:c8836c25027044348aed9a69ec877d4a2021-12-02T11:37:19ZGWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise10.1038/s41598-021-84534-w2045-2322https://doaj.org/article/c8836c25027044348aed9a69ec877d4a2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84534-whttps://doaj.org/toc/2045-2322Abstract Body size and weight show considerable variation both within and between species. This variation is controlled in part by genetics, but also strongly influenced by environmental factors including diet and the level of activity experienced by the individual. Due to the increasing obesity epidemic in much of the world, there is considerable interest in the genetic factors that control body weight and how weight changes in response to exercise treatments. Here, we address this question in the Drosophila model system, utilizing 38 strains of the Drosophila Genetics Reference Panel. We use GWAS to identify the molecular pathways that control weight and weight changes in response to exercise. We find that there is a complex set of molecular pathways controlling weight, with many genes linked to the central nervous system (CNS). The CNS also plays a role in the weight change with exercise, in particular, signaling from the CNS. Additional analyses revealed that weight in Drosophila is driven by two factors, animal size, and body composition, as the amount of fat mass versus lean mass impacts the density. Thus, while the CNS appears to be important for weight and exercise-induced weight change, signaling pathways are particularly important for determining how exercise impacts weight.Louis P. WatanabeNicole C. RiddleNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Louis P. Watanabe Nicole C. Riddle GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
description	Abstract Body size and weight show considerable variation both within and between species. This variation is controlled in part by genetics, but also strongly influenced by environmental factors including diet and the level of activity experienced by the individual. Due to the increasing obesity epidemic in much of the world, there is considerable interest in the genetic factors that control body weight and how weight changes in response to exercise treatments. Here, we address this question in the Drosophila model system, utilizing 38 strains of the Drosophila Genetics Reference Panel. We use GWAS to identify the molecular pathways that control weight and weight changes in response to exercise. We find that there is a complex set of molecular pathways controlling weight, with many genes linked to the central nervous system (CNS). The CNS also plays a role in the weight change with exercise, in particular, signaling from the CNS. Additional analyses revealed that weight in Drosophila is driven by two factors, animal size, and body composition, as the amount of fat mass versus lean mass impacts the density. Thus, while the CNS appears to be important for weight and exercise-induced weight change, signaling pathways are particularly important for determining how exercise impacts weight.
format	article
author	Louis P. Watanabe Nicole C. Riddle
author_facet	Louis P. Watanabe Nicole C. Riddle
author_sort	Louis P. Watanabe
title	GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
title_short	GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
title_full	GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
title_fullStr	GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
title_full_unstemmed	GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise
title_sort	gwas reveal a role for the central nervous system in regulating weight and weight change in response to exercise
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/c8836c25027044348aed9a69ec877d4a
work_keys_str_mv	AT louispwatanabe gwasrevealaroleforthecentralnervoussysteminregulatingweightandweightchangeinresponsetoexercise AT nicolecriddle gwasrevealaroleforthecentralnervoussysteminregulatingweightandweightchangeinresponsetoexercise
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GWAS reveal a role for the central nervous system in regulating weight and weight change in response to exercise

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