Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review

Organic compounds containing the F or B elements in their structures have recently attracted the interest of the chemists and medicinal chemists because their improved biological properties displayed in comparison to their non-fluorinated or non-borinated parent structures. It is widely been documen...

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Autores principales:	David Delgado, Rodrigo Abonia
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	Biologically active F- and B-containing compounds Biologically active curcumin-BF2 adducts and analogues BODIPÝs of biological interest Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/c884659c14e44175a03f4ef35f27c3ea
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spelling	oai:doaj.org-article:c884659c14e44175a03f4ef35f27c3ea2021-11-14T04:31:28ZSynthetic approaches for BF2-containing adducts of outstanding biological potential. A review1878-535210.1016/j.arabjc.2021.103528https://doaj.org/article/c884659c14e44175a03f4ef35f27c3ea2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1878535221005438https://doaj.org/toc/1878-5352Organic compounds containing the F or B elements in their structures have recently attracted the interest of the chemists and medicinal chemists because their improved biological properties displayed in comparison to their non-fluorinated or non-borinated parent structures. It is widely been documented that curcumine (CUR) have a high biological potential as antioxidant, anti-inflammatory and anticancer agent, among others, but some drawbacks related to its unfavorable bio-physicochemical properties have prevented its applicability as chemotherapeutic drug. Nevertheless, recent studies have shown that the introduction of the BF2 functionality in its structure (i.e. CUR-BF2 adducts) and analogues have significantly improved their biological properties, mainly, their anticancer and antibiotic activities.On the other hand, the BF2-adduct BODIPY (i.e. 4,4-difluoro-4-bora-3a-azonia-4a-aza-s-indacene) and derivatives are widely known by their outstanding photophysical properties displayed. However, recently it have increased the interest in such structures, but this time, for the biological properties that these fluorescent compounds are also shown, as convenient probes for diverse biological targets.Focusing on the above findings, we were interested into compile, in this review article, the literature documented since 2000–2020 exclusively engaged with the synthetic strategies established for the synthesis of curcumine-BF2 adducts, BODIPY and their related derivatives, in which the biological properties displayed by such structures have been highlighted. Remarkably, the biological activities displayed by the aforementioned BF2-based compounds are mainly related with cell imaging studies, biomolecules recognition and labels, antibiotic properties and antiproliferative agents, which were conveniently used to organize them in concise Tables and Schemes to facilitate their comparisons, and to underscore the key points of the present review.David DelgadoRodrigo AboniaElsevierarticleBiologically active F- and B-containing compoundsBiologically active curcumin-BF2 adducts and analoguesBODIPÝs of biological interestChemistryQD1-999ENArabian Journal of Chemistry, Vol 15, Iss 1, Pp 103528- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biologically active F- and B-containing compounds Biologically active curcumin-BF2 adducts and analogues BODIPÝs of biological interest Chemistry QD1-999
spellingShingle	Biologically active F- and B-containing compounds Biologically active curcumin-BF2 adducts and analogues BODIPÝs of biological interest Chemistry QD1-999 David Delgado Rodrigo Abonia Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
description	Organic compounds containing the F or B elements in their structures have recently attracted the interest of the chemists and medicinal chemists because their improved biological properties displayed in comparison to their non-fluorinated or non-borinated parent structures. It is widely been documented that curcumine (CUR) have a high biological potential as antioxidant, anti-inflammatory and anticancer agent, among others, but some drawbacks related to its unfavorable bio-physicochemical properties have prevented its applicability as chemotherapeutic drug. Nevertheless, recent studies have shown that the introduction of the BF2 functionality in its structure (i.e. CUR-BF2 adducts) and analogues have significantly improved their biological properties, mainly, their anticancer and antibiotic activities.On the other hand, the BF2-adduct BODIPY (i.e. 4,4-difluoro-4-bora-3a-azonia-4a-aza-s-indacene) and derivatives are widely known by their outstanding photophysical properties displayed. However, recently it have increased the interest in such structures, but this time, for the biological properties that these fluorescent compounds are also shown, as convenient probes for diverse biological targets.Focusing on the above findings, we were interested into compile, in this review article, the literature documented since 2000–2020 exclusively engaged with the synthetic strategies established for the synthesis of curcumine-BF2 adducts, BODIPY and their related derivatives, in which the biological properties displayed by such structures have been highlighted. Remarkably, the biological activities displayed by the aforementioned BF2-based compounds are mainly related with cell imaging studies, biomolecules recognition and labels, antibiotic properties and antiproliferative agents, which were conveniently used to organize them in concise Tables and Schemes to facilitate their comparisons, and to underscore the key points of the present review.
format	article
author	David Delgado Rodrigo Abonia
author_facet	David Delgado Rodrigo Abonia
author_sort	David Delgado
title	Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
title_short	Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
title_full	Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
title_fullStr	Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
title_full_unstemmed	Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review
title_sort	synthetic approaches for bf2-containing adducts of outstanding biological potential. a review
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/c884659c14e44175a03f4ef35f27c3ea
work_keys_str_mv	AT daviddelgado syntheticapproachesforbf2containingadductsofoutstandingbiologicalpotentialareview AT rodrigoabonia syntheticapproachesforbf2containingadductsofoutstandingbiologicalpotentialareview
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Synthetic approaches for BF2-containing adducts of outstanding biological potential. A review

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