Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder

Abstract Capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS) is a comprehensive, quantitative, and high throughput tool used to analyze metabolite profiles. In the present study, we used CE-TOFMS to profile metabolites found in the blood plasma of 33 medication-free patients with m...

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Autores principales:	Hidehiro Umehara, Shusuke Numata, Shin-ya Watanabe, Yutaka Hatakeyama, Makoto Kinoshita, Yukiko Tomioka, Kiyoshi Nakahara, Takeshi Nikawa, Tetsuro Ohmori
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c887db1cffd44455a26c571d49a5dda1
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spelling	oai:doaj.org-article:c887db1cffd44455a26c571d49a5dda12021-12-02T16:06:01ZAltered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder10.1038/s41598-017-05121-62045-2322https://doaj.org/article/c887db1cffd44455a26c571d49a5dda12017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05121-6https://doaj.org/toc/2045-2322Abstract Capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS) is a comprehensive, quantitative, and high throughput tool used to analyze metabolite profiles. In the present study, we used CE-TOFMS to profile metabolites found in the blood plasma of 33 medication-free patients with major depressive disorder (MDD) and 33 non-psychiatric control subjects. We then investigated changes which occurred in the metabolite levels during an 8-week treatment period. The medication-free MDD patients and control subjects showed significant differences in their mean levels of 33 metabolites, including kynurenine (KYN), glutamate (Glu), glutamine (Gln), methionine sulfoxide, and methionine (Met). In particular, the ratios of KYN to tryptophan (TRP), Gln to Glu, and Met to methionine sulfoxide were all significantly different between the two groups. Among the 33 metabolites with altered levels in MDD patients, the levels of KYN and Gln, as well as the ratio of Gln to Glu, were significantly normalized after treatment. Our findings suggest that imbalances in specific metabolite levels may be involved in the pathogenesis of MDD, and provide insight into the mechanisms by which antidepressant agents work in MDD patients.Hidehiro UmeharaShusuke NumataShin-ya WatanabeYutaka HatakeyamaMakoto KinoshitaYukiko TomiokaKiyoshi NakaharaTakeshi NikawaTetsuro OhmoriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hidehiro Umehara Shusuke Numata Shin-ya Watanabe Yutaka Hatakeyama Makoto Kinoshita Yukiko Tomioka Kiyoshi Nakahara Takeshi Nikawa Tetsuro Ohmori Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
description	Abstract Capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS) is a comprehensive, quantitative, and high throughput tool used to analyze metabolite profiles. In the present study, we used CE-TOFMS to profile metabolites found in the blood plasma of 33 medication-free patients with major depressive disorder (MDD) and 33 non-psychiatric control subjects. We then investigated changes which occurred in the metabolite levels during an 8-week treatment period. The medication-free MDD patients and control subjects showed significant differences in their mean levels of 33 metabolites, including kynurenine (KYN), glutamate (Glu), glutamine (Gln), methionine sulfoxide, and methionine (Met). In particular, the ratios of KYN to tryptophan (TRP), Gln to Glu, and Met to methionine sulfoxide were all significantly different between the two groups. Among the 33 metabolites with altered levels in MDD patients, the levels of KYN and Gln, as well as the ratio of Gln to Glu, were significantly normalized after treatment. Our findings suggest that imbalances in specific metabolite levels may be involved in the pathogenesis of MDD, and provide insight into the mechanisms by which antidepressant agents work in MDD patients.
format	article
author	Hidehiro Umehara Shusuke Numata Shin-ya Watanabe Yutaka Hatakeyama Makoto Kinoshita Yukiko Tomioka Kiyoshi Nakahara Takeshi Nikawa Tetsuro Ohmori
author_facet	Hidehiro Umehara Shusuke Numata Shin-ya Watanabe Yutaka Hatakeyama Makoto Kinoshita Yukiko Tomioka Kiyoshi Nakahara Takeshi Nikawa Tetsuro Ohmori
author_sort	Hidehiro Umehara
title	Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
title_short	Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
title_full	Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
title_fullStr	Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
title_full_unstemmed	Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
title_sort	altered kyn/trp, gln/glu, and met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c887db1cffd44455a26c571d49a5dda1
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Altered KYN/TRP, Gln/Glu, and Met/methionine sulfoxide ratios in the blood plasma of medication-free patients with major depressive disorder

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