Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection.

Legionella pneumophila (L. pneumophila), the causative agent of a severe form of pneumonia called Legionnaires' disease, replicates in human monocytes and macrophages. Most inbred mouse strains are restrictive to L. pneumophila infection except for the A/J, Nlrc4(-/-) (Ipaf(-/-)), and caspase-1...

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Bibliographic Details
Main Authors: Anwari Akhter, Mikhail A Gavrilin, Laura Frantz, Songcerae Washington, Cameron Ditty, Dominique Limoli, Colby Day, Anasuya Sarkar, Christie Newland, Jonathan Butchar, Clay B Marsh, Mark D Wewers, Susheela Tridandapani, Thirumala-Devi Kanneganti, Amal O Amer
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2009
Subjects:
Immunologic diseases. Allergy
RC581-607
Biology (General)
QH301-705.5
Online Access:https://doaj.org/article/c8897397390641b9852ccea43588c3f0
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https://doaj.org/article/c8897397390641b9852ccea43588c3f0

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