Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer
Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings suggest that cell-autonomous immune gene repressio...
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Nature Portfolio
2021
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oai:doaj.org-article:c88977f0af0c4f029def4e50d414f3bb2021-12-02T13:33:50ZCell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer10.1038/s42003-021-01842-72399-3642https://doaj.org/article/c88977f0af0c4f029def4e50d414f3bb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01842-7https://doaj.org/toc/2399-3642Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings suggest that cell-autonomous immune gene repression is a shared feature between healthy and tumor cells of NE lineage and may influence tumor-immune cell interaction and response to immunotherapy.Ling CaiHongyu LiuFang HuangJunya FujimotoLuc GirardJun ChenYongwen LiYu-An ZhangDhruba DebVictor StastnyKarine PozoChristin S. KuoGaoxiang JiaChendong YangWei ZouAdeeb AlomarKenneth HuffmanMahboubeh Papari-ZareeiLin YangBenjamin DrapkinEsra A. AkbayDavid S. ShamesIgnacio I. WistubaTao WangJane E. JohnsonGuanghua XiaoRalph J. DeBerardinisJohn D. MinnaYang XieAdi F. GazdarNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Biology (General) QH301-705.5 |
| spellingShingle |
Biology (General) QH301-705.5 Ling Cai Hongyu Liu Fang Huang Junya Fujimoto Luc Girard Jun Chen Yongwen Li Yu-An Zhang Dhruba Deb Victor Stastny Karine Pozo Christin S. Kuo Gaoxiang Jia Chendong Yang Wei Zou Adeeb Alomar Kenneth Huffman Mahboubeh Papari-Zareei Lin Yang Benjamin Drapkin Esra A. Akbay David S. Shames Ignacio I. Wistuba Tao Wang Jane E. Johnson Guanghua Xiao Ralph J. DeBerardinis John D. Minna Yang Xie Adi F. Gazdar Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| description |
Ling Cai et al. used transcriptomic profiling data of healthy lung, patient-derived small cell lung cancer cell lines, xenografts, and primary tumors to examine a link between neuroendocrine (NE) signatures and immune gene expression. Their findings suggest that cell-autonomous immune gene repression is a shared feature between healthy and tumor cells of NE lineage and may influence tumor-immune cell interaction and response to immunotherapy. |
| format |
article |
| author |
Ling Cai Hongyu Liu Fang Huang Junya Fujimoto Luc Girard Jun Chen Yongwen Li Yu-An Zhang Dhruba Deb Victor Stastny Karine Pozo Christin S. Kuo Gaoxiang Jia Chendong Yang Wei Zou Adeeb Alomar Kenneth Huffman Mahboubeh Papari-Zareei Lin Yang Benjamin Drapkin Esra A. Akbay David S. Shames Ignacio I. Wistuba Tao Wang Jane E. Johnson Guanghua Xiao Ralph J. DeBerardinis John D. Minna Yang Xie Adi F. Gazdar |
| author_facet |
Ling Cai Hongyu Liu Fang Huang Junya Fujimoto Luc Girard Jun Chen Yongwen Li Yu-An Zhang Dhruba Deb Victor Stastny Karine Pozo Christin S. Kuo Gaoxiang Jia Chendong Yang Wei Zou Adeeb Alomar Kenneth Huffman Mahboubeh Papari-Zareei Lin Yang Benjamin Drapkin Esra A. Akbay David S. Shames Ignacio I. Wistuba Tao Wang Jane E. Johnson Guanghua Xiao Ralph J. DeBerardinis John D. Minna Yang Xie Adi F. Gazdar |
| author_sort |
Ling Cai |
| title |
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| title_short |
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| title_full |
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| title_fullStr |
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| title_full_unstemmed |
Cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| title_sort |
cell-autonomous immune gene expression is repressed in pulmonary neuroendocrine cells and small cell lung cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c88977f0af0c4f029def4e50d414f3bb |
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