A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background correction.

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Autores principales:	Nicholas M. Pearce, Tobias Krojer, Anthony R. Bradley, Patrick Collins, Radosław P. Nowak, Romain Talon, Brian D. Marsden, Sebastian Kelm, Jiye Shi, Charlotte M. Deane, Frank von Delft
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b7
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spelling	oai:doaj.org-article:c88bb825cf794f33ac6c39f01dd123b72021-12-02T15:38:34ZA multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density10.1038/ncomms151232041-1723https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b72017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15123https://doaj.org/toc/2041-1723Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background correction.Nicholas M. PearceTobias KrojerAnthony R. BradleyPatrick CollinsRadosław P. NowakRomain TalonBrian D. MarsdenSebastian KelmJiye ShiCharlotte M. DeaneFrank von DelftNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas M. Pearce Tobias Krojer Anthony R. Bradley Patrick Collins Radosław P. Nowak Romain Talon Brian D. Marsden Sebastian Kelm Jiye Shi Charlotte M. Deane Frank von Delft A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
description	Building a ligand into a weak region of an electron density map of a protein is a subjective process. Here, the authors present a new method to obtain a clear electron density for a bound ligand based on multi-crystal experiments and 3D background correction.
format	article
author	Nicholas M. Pearce Tobias Krojer Anthony R. Bradley Patrick Collins Radosław P. Nowak Romain Talon Brian D. Marsden Sebastian Kelm Jiye Shi Charlotte M. Deane Frank von Delft
author_facet	Nicholas M. Pearce Tobias Krojer Anthony R. Bradley Patrick Collins Radosław P. Nowak Romain Talon Brian D. Marsden Sebastian Kelm Jiye Shi Charlotte M. Deane Frank von Delft
author_sort	Nicholas M. Pearce
title	A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
title_short	A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
title_full	A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
title_fullStr	A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
title_full_unstemmed	A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
title_sort	multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/c88bb825cf794f33ac6c39f01dd123b7
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A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density

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