PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells

PERK signaling through C/EBPδ contributes to ER stress-induced expression of immunomodulatory and tumor promoting chemokines by cancer cells

Abstract Cancer cells experience endoplasmic reticulum (ER) stress due to activated oncogenes and conditions of nutrient deprivation and hypoxia. The ensuing unfolded protein response (UPR) is executed by ATF6, IRE1 and PERK pathways. Adaptation to mild ER stress promotes tumor cell survival and agg...

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Autores principales: Namratha Sheshadri, Dipak K. Poria, Shikha Sharan, Ying Hu, Chunhua Yan, Vishal N. Koparde, Kuppusamy Balamurugan, Esta Sterneck
Formato: article
Lenguaje:EN
Publicado: Nature Publishing Group 2021
Materias:
Cytology
QH573-671
Acceso en línea:https://doaj.org/article/c88cd23c0636472a90c4d08c51983d7f
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