Sarcoma classification by DNA methylation profiling
Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.
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Nature Portfolio
2021
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oai:doaj.org-article:c88e43d5043848c8bc27777e780e6d5b2021-12-02T14:19:11ZSarcoma classification by DNA methylation profiling10.1038/s41467-020-20603-42041-1723https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20603-4https://doaj.org/toc/2041-1723Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes.Christian KoelscheDaniel SchrimpfDamian StichelMartin SillFelix SahmDavid E. ReussMirjam BlattnerBarbara WorstChristoph E. HeiligKatja BeckPeter HorakSimon KreutzfeldtElke PaffSebastian StarkPascal JohannFlorian SeltJonas EckerDominik SturmKristian W. PajtlerAnnekathrin ReinhardtAnnika K. WefersPhilipp SieversAzadeh EbrahimiAbigail SuwalaFrancisco Fernández-KlettBelén CasaliniAndrey KorshunovVolker HovestadtFelix K. F. KommossMark KriegsmannMatthias SchickMelanie Bewerunge-HudlerTill MildeOlaf WittAndreas E. KulozikMarcel KoolLaura Romero-PérezThomas G. P. GrünewaldThomas KirchnerWolfgang WickMichael PlattenAndreas UnterbergMatthias UhlAmir AbdollahiJürgen DebusBurkhard LehnerChristian ThomasMartin HasselblattWerner PaulusChristian HartmannOri StaszewskiMarco PrinzJürgen HenchStephan FrankYvonne M. H. Versleijen-JonkersMarije E. WeidemaThomas MentzelKlaus GriewankEnrique de ÁlavaJuan Díaz MartínMiguel A. Idoate GastearenaKenneth Tou-En ChangSharon Yin Yee LowAdrian Cuevas-BourdierMichel MittelbronnMartin MynarekStefan RutkowskiUlrich SchüllerViktor F. MautnerJens SchittenhelmJonathan SerranoMatija SnuderlReinhard BüttnerThomas KlingebielRolf BusleiManfred GesslerPieter WesselingWinand N. M. DinjensSebastian BrandnerZane JaunmuktaneIben LyskjærPeter SchirmacherAlbrecht StenzingerBenedikt BrorsHanno GlimmChristoph HeiningOscar M. TiradoMiguel Sáinz-JaspeadoJaume MoraJavier AlonsoXavier Garcia del MuroSebastian MoranManel EstellerJamal K. BenhamidaMarc LadanyiEva WardelmannCristina AntonescuAdrienne FlanaganUta DirksenPeter HohenbergerDaniel BaumhoerWolfgang HartmannChristian VokuhlUta FluckeIver PetersenGunhild MechtersheimerDavid CapperDavid T. W. JonesStefan FröhlingStefan M. PfisterAndreas von DeimlingNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Science Q |
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Science Q Christian Koelsche Daniel Schrimpf Damian Stichel Martin Sill Felix Sahm David E. Reuss Mirjam Blattner Barbara Worst Christoph E. Heilig Katja Beck Peter Horak Simon Kreutzfeldt Elke Paff Sebastian Stark Pascal Johann Florian Selt Jonas Ecker Dominik Sturm Kristian W. Pajtler Annekathrin Reinhardt Annika K. Wefers Philipp Sievers Azadeh Ebrahimi Abigail Suwala Francisco Fernández-Klett Belén Casalini Andrey Korshunov Volker Hovestadt Felix K. F. Kommoss Mark Kriegsmann Matthias Schick Melanie Bewerunge-Hudler Till Milde Olaf Witt Andreas E. Kulozik Marcel Kool Laura Romero-Pérez Thomas G. P. Grünewald Thomas Kirchner Wolfgang Wick Michael Platten Andreas Unterberg Matthias Uhl Amir Abdollahi Jürgen Debus Burkhard Lehner Christian Thomas Martin Hasselblatt Werner Paulus Christian Hartmann Ori Staszewski Marco Prinz Jürgen Hench Stephan Frank Yvonne M. H. Versleijen-Jonkers Marije E. Weidema Thomas Mentzel Klaus Griewank Enrique de Álava Juan Díaz Martín Miguel A. Idoate Gastearena Kenneth Tou-En Chang Sharon Yin Yee Low Adrian Cuevas-Bourdier Michel Mittelbronn Martin Mynarek Stefan Rutkowski Ulrich Schüller Viktor F. Mautner Jens Schittenhelm Jonathan Serrano Matija Snuderl Reinhard Büttner Thomas Klingebiel Rolf Buslei Manfred Gessler Pieter Wesseling Winand N. M. Dinjens Sebastian Brandner Zane Jaunmuktane Iben Lyskjær Peter Schirmacher Albrecht Stenzinger Benedikt Brors Hanno Glimm Christoph Heining Oscar M. Tirado Miguel Sáinz-Jaspeado Jaume Mora Javier Alonso Xavier Garcia del Muro Sebastian Moran Manel Esteller Jamal K. Benhamida Marc Ladanyi Eva Wardelmann Cristina Antonescu Adrienne Flanagan Uta Dirksen Peter Hohenberger Daniel Baumhoer Wolfgang Hartmann Christian Vokuhl Uta Flucke Iver Petersen Gunhild Mechtersheimer David Capper David T. W. Jones Stefan Fröhling Stefan M. Pfister Andreas von Deimling Sarcoma classification by DNA methylation profiling |
| description |
Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classification for research and clinical purposes. |
| format |
article |
| author |
Christian Koelsche Daniel Schrimpf Damian Stichel Martin Sill Felix Sahm David E. Reuss Mirjam Blattner Barbara Worst Christoph E. Heilig Katja Beck Peter Horak Simon Kreutzfeldt Elke Paff Sebastian Stark Pascal Johann Florian Selt Jonas Ecker Dominik Sturm Kristian W. Pajtler Annekathrin Reinhardt Annika K. Wefers Philipp Sievers Azadeh Ebrahimi Abigail Suwala Francisco Fernández-Klett Belén Casalini Andrey Korshunov Volker Hovestadt Felix K. F. Kommoss Mark Kriegsmann Matthias Schick Melanie Bewerunge-Hudler Till Milde Olaf Witt Andreas E. Kulozik Marcel Kool Laura Romero-Pérez Thomas G. P. Grünewald Thomas Kirchner Wolfgang Wick Michael Platten Andreas Unterberg Matthias Uhl Amir Abdollahi Jürgen Debus Burkhard Lehner Christian Thomas Martin Hasselblatt Werner Paulus Christian Hartmann Ori Staszewski Marco Prinz Jürgen Hench Stephan Frank Yvonne M. H. Versleijen-Jonkers Marije E. Weidema Thomas Mentzel Klaus Griewank Enrique de Álava Juan Díaz Martín Miguel A. Idoate Gastearena Kenneth Tou-En Chang Sharon Yin Yee Low Adrian Cuevas-Bourdier Michel Mittelbronn Martin Mynarek Stefan Rutkowski Ulrich Schüller Viktor F. Mautner Jens Schittenhelm Jonathan Serrano Matija Snuderl Reinhard Büttner Thomas Klingebiel Rolf Buslei Manfred Gessler Pieter Wesseling Winand N. M. Dinjens Sebastian Brandner Zane Jaunmuktane Iben Lyskjær Peter Schirmacher Albrecht Stenzinger Benedikt Brors Hanno Glimm Christoph Heining Oscar M. Tirado Miguel Sáinz-Jaspeado Jaume Mora Javier Alonso Xavier Garcia del Muro Sebastian Moran Manel Esteller Jamal K. Benhamida Marc Ladanyi Eva Wardelmann Cristina Antonescu Adrienne Flanagan Uta Dirksen Peter Hohenberger Daniel Baumhoer Wolfgang Hartmann Christian Vokuhl Uta Flucke Iver Petersen Gunhild Mechtersheimer David Capper David T. W. Jones Stefan Fröhling Stefan M. Pfister Andreas von Deimling |
| author_facet |
Christian Koelsche Daniel Schrimpf Damian Stichel Martin Sill Felix Sahm David E. Reuss Mirjam Blattner Barbara Worst Christoph E. Heilig Katja Beck Peter Horak Simon Kreutzfeldt Elke Paff Sebastian Stark Pascal Johann Florian Selt Jonas Ecker Dominik Sturm Kristian W. Pajtler Annekathrin Reinhardt Annika K. Wefers Philipp Sievers Azadeh Ebrahimi Abigail Suwala Francisco Fernández-Klett Belén Casalini Andrey Korshunov Volker Hovestadt Felix K. F. Kommoss Mark Kriegsmann Matthias Schick Melanie Bewerunge-Hudler Till Milde Olaf Witt Andreas E. Kulozik Marcel Kool Laura Romero-Pérez Thomas G. P. Grünewald Thomas Kirchner Wolfgang Wick Michael Platten Andreas Unterberg Matthias Uhl Amir Abdollahi Jürgen Debus Burkhard Lehner Christian Thomas Martin Hasselblatt Werner Paulus Christian Hartmann Ori Staszewski Marco Prinz Jürgen Hench Stephan Frank Yvonne M. H. Versleijen-Jonkers Marije E. Weidema Thomas Mentzel Klaus Griewank Enrique de Álava Juan Díaz Martín Miguel A. Idoate Gastearena Kenneth Tou-En Chang Sharon Yin Yee Low Adrian Cuevas-Bourdier Michel Mittelbronn Martin Mynarek Stefan Rutkowski Ulrich Schüller Viktor F. Mautner Jens Schittenhelm Jonathan Serrano Matija Snuderl Reinhard Büttner Thomas Klingebiel Rolf Buslei Manfred Gessler Pieter Wesseling Winand N. M. Dinjens Sebastian Brandner Zane Jaunmuktane Iben Lyskjær Peter Schirmacher Albrecht Stenzinger Benedikt Brors Hanno Glimm Christoph Heining Oscar M. Tirado Miguel Sáinz-Jaspeado Jaume Mora Javier Alonso Xavier Garcia del Muro Sebastian Moran Manel Esteller Jamal K. Benhamida Marc Ladanyi Eva Wardelmann Cristina Antonescu Adrienne Flanagan Uta Dirksen Peter Hohenberger Daniel Baumhoer Wolfgang Hartmann Christian Vokuhl Uta Flucke Iver Petersen Gunhild Mechtersheimer David Capper David T. W. Jones Stefan Fröhling Stefan M. Pfister Andreas von Deimling |
| author_sort |
Christian Koelsche |
| title |
Sarcoma classification by DNA methylation profiling |
| title_short |
Sarcoma classification by DNA methylation profiling |
| title_full |
Sarcoma classification by DNA methylation profiling |
| title_fullStr |
Sarcoma classification by DNA methylation profiling |
| title_full_unstemmed |
Sarcoma classification by DNA methylation profiling |
| title_sort |
sarcoma classification by dna methylation profiling |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/c88e43d5043848c8bc27777e780e6d5b |
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