Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis

Abstract Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage m...

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Autores principales:	Yuzo Suzuki, Masahiro Shirai, Kazuhiro Asada, Hideki Yasui, Masato Karayama, Hironao Hozumi, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Naoki Inui, Toshihiro Shirai, Hiroshi Hayakawa, Takafumi Suda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/c88febf4a56d4eaea5212018d3422adb
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spelling	oai:doaj.org-article:c88febf4a56d4eaea5212018d3422adb2021-12-02T15:08:15ZMacrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis10.1038/s41598-018-31565-52045-2322https://doaj.org/article/c88febf4a56d4eaea5212018d3422adb2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-31565-5https://doaj.org/toc/2045-2322Abstract Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage mannose receptor, sCD206, in PTB and examined its clinical significance. First, the concentration of sCD206 was measured in the sera of 96 patients with PTB (Tenryu cohort), and in pleural effusions from 29 patients with TB pleurisy. These were verified in another independent cohort (Shizuoka cohort). We found increased concentrations of sCD206 in sera, but not in pleural effusions of PTB patients. Notably, PTB patients with poor prognosis showed significantly higher levels of serum sCD206. At a cut-off value of 1,600 ng/mL in the Tenryu cohort, sCD206 predicted prognosis of PTB with area under the curve 0.847, sensitivity 77.3%, and specificity 86.5%. These results were validated in the Shizuoka cohort. Pathological analyses showed concordance of enhanced CD206 expression in lung and pleural tissues with caseating granuloma in TB. Serum sCD206 increased in PTB and was associated with prognosis. sCD206 is a potential biomarker for PTB.Yuzo SuzukiMasahiro ShiraiKazuhiro AsadaHideki YasuiMasato KarayamaHironao HozumiKazuki FuruhashiNoriyuki EnomotoTomoyuki FujisawaYutaro NakamuraNaoki InuiToshihiro ShiraiHiroshi HayakawaTakafumi SudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuzo Suzuki Masahiro Shirai Kazuhiro Asada Hideki Yasui Masato Karayama Hironao Hozumi Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Toshihiro Shirai Hiroshi Hayakawa Takafumi Suda Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
description	Abstract Tuberculosis (TB) remains a leading cause of fatal infectious disease. Accumulations of macrophages are found in infected sites; thus, we hypothesized that a marker of activated macrophages may be related to prognosis of pulmonary TB (PTB). This study investigated serum soluble macrophage mannose receptor, sCD206, in PTB and examined its clinical significance. First, the concentration of sCD206 was measured in the sera of 96 patients with PTB (Tenryu cohort), and in pleural effusions from 29 patients with TB pleurisy. These were verified in another independent cohort (Shizuoka cohort). We found increased concentrations of sCD206 in sera, but not in pleural effusions of PTB patients. Notably, PTB patients with poor prognosis showed significantly higher levels of serum sCD206. At a cut-off value of 1,600 ng/mL in the Tenryu cohort, sCD206 predicted prognosis of PTB with area under the curve 0.847, sensitivity 77.3%, and specificity 86.5%. These results were validated in the Shizuoka cohort. Pathological analyses showed concordance of enhanced CD206 expression in lung and pleural tissues with caseating granuloma in TB. Serum sCD206 increased in PTB and was associated with prognosis. sCD206 is a potential biomarker for PTB.
format	article
author	Yuzo Suzuki Masahiro Shirai Kazuhiro Asada Hideki Yasui Masato Karayama Hironao Hozumi Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Toshihiro Shirai Hiroshi Hayakawa Takafumi Suda
author_facet	Yuzo Suzuki Masahiro Shirai Kazuhiro Asada Hideki Yasui Masato Karayama Hironao Hozumi Kazuki Furuhashi Noriyuki Enomoto Tomoyuki Fujisawa Yutaro Nakamura Naoki Inui Toshihiro Shirai Hiroshi Hayakawa Takafumi Suda
author_sort	Yuzo Suzuki
title	Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_short	Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_full	Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_fullStr	Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_full_unstemmed	Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis
title_sort	macrophage mannose receptor, cd206, predict prognosis in patients with pulmonary tuberculosis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/c88febf4a56d4eaea5212018d3422adb
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_version_	1718388213920301056

Macrophage mannose receptor, CD206, predict prognosis in patients with pulmonary tuberculosis

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